Abstract

SUERO-GARCIA, Carlos; MARTIN-BANDERAS, Lucia  and  HOLGADO, Mª Ángeles. Neuroprotective Effect of Cannabinoids in Neurodegenerative Diseases. Ars Pharm [online]. 2015, vol.56, n.2, pp.77-87. ISSN 2340-9894.  https://dx.doi.org/10.4321/S2340-98942015000200002.

Objectives: It is analysed the actual situation of the investigations related to cannabinoids substances, as well as their interaction with the organism, classification, therapeutics effects and their use in neurodegenerative diseases. Methods: This study is based on the review of multiples scientific articles directly related with the cannabinoides substance and its synthetic derivates, with a special attention on the way the organism interacts and the effects the substances cause in it. Specifically, the study will get deep into the neuroantiinflammatory and analgesic effects of these substances, related with the neuroprotector effect in neurodegenerative diseases such as Alzheimer, Parkinson, Multiple Sclerosis and Amyotrophic Lateral Sclerosis. Results: From thousands years, the Cannabis Sativa has been used by multiples cultures with different purposes such as joy, textile, analgesics etc. But is not till ends of the XX century when there are diverse scientific studies related with the Cannabis encouraged. The plant has 400 components, 60 of them belong to the cannabinoides group. The main ones are cannabinol, cannabidiol and tetrahidrocannabinol. With the discoverment of the cannabinoids substances, its derivates, and the receptors which interact with them, it is increased the therapeutic possibilities and remarking the neuroprotective effect which these substances contain. Conclusions: It has been demostraded the huge potential of the cannabinoids as therapeutic substances apart from its analgesic and antiemetic uses, that is, neurodegenaritve diseases in which they can not only decrease its symptons but stop disease process. Another possible application could be in the oncologic area, being particularly intense the investigation's activity realised the last 15 years.

Keywords : Cannabis Sativa; cannabinoids; neuroprotection; neurodegeneration; cancer.

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