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Ars Pharmaceutica (Internet)
On-line version ISSN 2340-9894
Abstract
APEJI, Yonni Eshovo et al. Performance evaluation of maize starch as a multifunctional excipient in metronidazole tablet formulation. Ars Pharm [online]. 2019, vol.60, n.3, pp.161-167. Epub Mar 09, 2020. ISSN 2340-9894. https://dx.doi.org/10.30827/ars.v60i3.9289.
Objective:
The aim of this study was to evaluate the performance of maize starch as a multifunctional excipient in metronidazole tablet formulation.
Methods:
Metronidazole tablets were prepared by wet granulation containing maize starch as diluent (40 %), disintegrant (10 %), and binder (5 %) and compared with a reference formulation containing lactose as diluent (40 %), maize starch as disintegrant (10 %) and acacia as binder (5 %). The granules were analysed for particle size, flow properties, compressibility and moisture content. Tablets weighing 500 mg were compressed for both formulations on a Single Punch Tablet Press using a 12 mm flat-faced punches at 57.5 MPa. The tablets were kept for 24 h to allow for elastic recovery and evaluated for weight and content uniformity, thickness, crushing strength, friability, disintegration time and in vitro drug release.
Results:
The granule properties revealed differences in mean granule size, angle of repose, bulk and tapped densities for both formulations. Batch I tablets gave rise to better tableting properties compared to batch II tablets.
Conclusion:
This study confirms the suitability of maize starch as a multifunctional excipient in tablet formulation.
Keywords : Maize starch; multifunctional excipient; granules; tableting.