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Ars Pharmaceutica (Internet)

On-line version ISSN 2340-9894


VILLEGAS-MENDOZA, Jesús M et al. Antimicrobial evaluation of a methanol extract of Beauveria bassiana against pathogenic bacteria of nosocomial importance. Ars Pharm [online]. 2019, vol.60, n.3, pp.169-176.  Epub Mar 09, 2020. ISSN 2340-9894.


The antimicrobial activity of a crude extract of B. bassiana and two fractions thereof against clinically important bacteria was evaluated.


The mycelium of strain B. bassiana was soaked in methanol for a week, then it was evaporated in a rotovap at 45 ° C applying a vacuum. The methanolic extract was passed through two mobile phases to obtain a fraction A and B. Fractions A, B and crude extract C were evaluated against the strains Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Salmonella tiphy, Pseudomonas aeruginosa and Acinetobacter baumannii with the plate microdilution technique.


In fraction A an antimicrobial effect against Salmonella typhi, Pseudomonas aeruginosa and Acinetobacter baumannii was observed, bacterial growth reached 70, 60 and 83% respectively. Fraction B caused an antimicrobial effect in Klebsiella pneumoniae, S. typhi, P. aeruginosa and A. baumannii with a bacterial growth of 62, 58, 41 and 7% respectively. And the crude extract did not cause growth inhibition in A. baumannii, but for the rest of the bacteria there was a growth of 56 to 88%.


Beauveria bassiana is an entomopathogenic fungus that produces different metabolites with insecticidal, cytotoxic, antifungal, antibiotic and antiviral activity. This is the first study of the antimicrobial effects of a methanolic extract of the entomopathogenic fungus B. bassiana against bacterial strains of clinical importance.

Keywords : Pathogenic bacteria; Beauveria bassiana; Antimicrobial.

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