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Ars Pharmaceutica (Internet)

On-line version ISSN 2340-9894

Abstract

ORSI, Valéria C. et al. Bran of cassava starch flour and bran of cassava flour as potential tablet excipients. Ars Pharm [online]. 2019, vol.60, n.4, pp.205-211.  Epub Mar 09, 2020. ISSN 2340-9894.  http://dx.doi.org/10.30827/ars.v60i4.9385.

Objectives:

The physicochemical characteristics of bran of cassava starch flour and bran of cassava flour (viz. organoleptic characteristics, pH value, moisture content, total ashes, lipid, protein, starch and fiber contents) and biopharmacotechnical parameters (viz. granulometry, flow capacity, angle at rest, outflow time and apparent density) were evaluated aiming at assessing their potential use as tablet excipients.

Methodos:

Three tablet formulations of venlafaxine hydrochloride were proposed, having as excipients bran of cassava flour, bran of cassava starch flour and Starch 1500®. The tablets were produced using two different pressures (98±5 MPa and 32±6 Mpa) and their mechanical (hardness and friability) and dissolubility characteristics were evaluated.

Results and Conclusions:

The tablets produced with both cassava flours, using higher pressures, presented similar physicochemical characteristics to those obtained with the excipient Starch1500®, thus indicating that cassava flours possess the potential to be used as disintegrating agents in tablets.

Keywords : excipient; tablets; Manihot esculenta.

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