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Ars Pharmaceutica (Internet)

On-line version ISSN 2340-9894

Abstract

SINGH, Namita; KUSHWAHA, Poonam; AHMAD, Usama  and  ABDULLAH, Mohammad. Proliposomes: an approach for the development of stable liposome. Ars Pharm [online]. 2019, vol.60, n.4, pp.231-240.  Epub Mar 09, 2020. ISSN 2340-9894.  http://dx.doi.org/10.30827/ars.v60i4.8517.

Background:

For several years, many attempts have been made for the improvement of liposomal stability. In 1986, Payne et al, introduced the concept of Pro-liposome for liposome preparation in order to avoid physicochemical instability encountered in some liposome suspensions such as aggregation, fusion, hydrolysis, and/or oxidation.

Objective:

The objective of this review is to focus on different aspects related to Proliposomes, their method of preparation, characterization techniques and pointing out its scope in drug delivery systems.

Methods:

Proliposomes are a new form of drug delivery systems. They are dry, free-flowing granular products composed of drug and phospholipid which, upon addition of water, disperse to form a multi-lamellar liposomal suspension.

Results and Discussion:

These Proliposomes are nearly as good as or perhaps better than conventional liposomes. In the present review attempt has been made to briefly explain the concept of Proliposomes with a focus on its components, preparation, characterizations and their field of application.

Conclusion:

Extensive survey of literatures and collected data suggests that Pro-liposomes are promising drug carriers for the future.

Keywords : Liposome; Proliposome; Stability; Bioavailability; Phospholipid; Cholesterol.

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