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Ars Pharmaceutica (Internet)

On-line version ISSN 2340-9894


SINGH, Namita; KUSHWAHA, Poonam; AHMAD, Usama  and  ABDULLAH, Mohammad. Proliposomes: an approach for the development of stable liposome. Ars Pharm [online]. 2019, vol.60, n.4, pp.231-240.  Epub Mar 09, 2020. ISSN 2340-9894.


For several years, many attempts have been made for the improvement of liposomal stability. In 1986, Payne et al, introduced the concept of Pro-liposome for liposome preparation in order to avoid physicochemical instability encountered in some liposome suspensions such as aggregation, fusion, hydrolysis, and/or oxidation.


The objective of this review is to focus on different aspects related to Proliposomes, their method of preparation, characterization techniques and pointing out its scope in drug delivery systems.


Proliposomes are a new form of drug delivery systems. They are dry, free-flowing granular products composed of drug and phospholipid which, upon addition of water, disperse to form a multi-lamellar liposomal suspension.

Results and Discussion:

These Proliposomes are nearly as good as or perhaps better than conventional liposomes. In the present review attempt has been made to briefly explain the concept of Proliposomes with a focus on its components, preparation, characterizations and their field of application.


Extensive survey of literatures and collected data suggests that Pro-liposomes are promising drug carriers for the future.

Keywords : Liposome; Proliposome; Stability; Bioavailability; Phospholipid; Cholesterol.

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