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Ars Pharmaceutica (Internet)

On-line version ISSN 2340-9894

Abstract

RUIZ-BRAVO, Alfonso  and  JIMENEZ-VALERA, María. SARS-CoV-2 and acute respiratory síndrome pandemic (COVID-19). Ars Pharm [online]. 2020, vol.61, n.2, pp.63-79.  Epub July 20, 2020. ISSN 2340-9894.  http://dx.doi.org/10.30827/ars.v61i2.15177.

Introduction:

In December 2019, the first cases of respiratory disease caused by an emerging coronavirus were detected. The causative agento f the outbreak was called SARS-CoV-2, and in the first months of 2020 it spread throughout the world as a pandemic.

Method:

The most relevant publications concerned with the aims of the review were examined.

Results:

The disease, known as COVID-19. Patients show cough, fever, and respiratory distress. The most severe forms, mainly affecting the elderly and associated with various comorbidities, are manifested by impaired respiratory function, requiring mechanical ventilation, and systemic inflammatory response syndrome, which can lead to septic shock with multi-organ failure and high mortality rates. This review examines the current state of knowledge about the characteristics and origin of SARS-CoV-2, its replication, and the pathogenesis, clinical, diagnosis, treatment, and prevention of COVID-19.

Conclusions:

The characteristics of SARS-CoV-2 and the clinical manifestations of COVID-19 are well known. PCR is the reference technique for laboratory diagnosis; assays for the detection of antigens and antibodies are available, with optimization possibilities. Treatment protocols include attenuation of the systemic inflammatory response and administration of antiviral agents. There are vaccines in development.

Keywords : SARS-CoV-2; COVID-19; Coronavirus.

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