SciELO - Scientific Electronic Library Online

 
vol.61 issue2Interruption of breast feeding related to drugs consumptionA prospective interventional study on comorbidities, drug - drug interactions and its management among cancer author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Ars Pharmaceutica (Internet)

On-line version ISSN 2340-9894

Abstract

MAKHMAL ZADEH, Behzad Sharif  and  BAHMANPUR, Mehrnoosh. The reduction in iodine absorption through rat skin by polymeric micelles in comparison with Povidone-Iodine: an ex-vivo study. Ars Pharm [online]. 2020, vol.61, n.2, pp.105-112.  Epub July 20, 2020. ISSN 2340-9894.  http://dx.doi.org/10.30827/ars.v61i2.9997.

Background:

topical antiseptic agents have been used widely in normal skin and wound which is associated with side effects such as systemic toxicity.

Objective:

Iodine is a non-metallic agent with an antimicrobial property that is used in the clinic as antiseptic. Iodophores such as Povidone-Iodine (PVP-I) introduced to improve the stability of the aqueous solution of iodine. Time taking and expensive procedures for producing complex between iodine and polyvinyl pyrolidine and systemic iodine absorption after topical PVP-I application are limitations on the application of this iodophore. The aim of this study was the design and evaluation of polymeric micelles for the overcoming of PVP-I limitations.

Methods:

Eight polymeric micelle formulations prepared by the thin-layer method based on full-factorial design. In an ex-vivo study permeability of iodine- loaded in polymeric micelles through rat skin was evaluated in comparison with PVP-I.

Results:

polymeric micelles demonstrated particle size between 14-153 nm that is affected by critical micelle concentration (CMC) and molecular weight of the polymer. Maximum % of drug released after 24 h was 62.3% that mainly controlled by the type of polymer. All polymeric micelles significantly decreased the percentage of drug permeated through rat skin and so decreased the risk of iodine toxicity. The minimum bactericidal concentration of polymeric micelles was comparable with PVP-I.

Conclusion:

Polymeric micelle demonstrated a perfect topical carrier for iodine loading and delivery through the skin by Iodine entrapment into the skin and sufficiently antimicrobial effect.

Keywords : Polymeric micelles; Povidone-Iodine; Skin permeation; Iodine toxicity.

        · abstract in Spanish     · text in English     · English ( pdf )