SciELO - Scientific Electronic Library Online

 
vol.61 issue3Dermocosmetic's regulation and terminology: the origins of the INCI norms in SpainMeasurement of the patient's knowledge about his antidiabetic medication: systematic review author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Ars Pharmaceutica (Internet)

On-line version ISSN 2340-9894

Abstract

CHAVEZ-ALCANTARA, Leyly; CABANILLAS-VARGAS, Yesica; RUIZ-REYES, Segundo  and  GUEVARA-VASQUEZ, Ana María. Phytochemical screening and hepatoprotective potential of Niphidium albopunctatissimum Lellinger on alcoholic hepatoxicity induced in albino rats. Ars Pharm [online]. 2020, vol.61, n.3, pp.187-192.  Epub Aug 17, 2020. ISSN 2340-9894.  http://dx.doi.org/10.30827/ars.v61i3.13634.

Objectives:

To identify the phytoconstituents and determine the effect of Niphidium albopunctatissimum Lellinger on alcoholic hepatoxicity induced in albino rats.

Methods:

Phytochemical screening was performed using the drop Test. For hepatoxicity study, albino rats were randomized into 5 groups of 6 each. Healthy group: without hepatoxicity; Control group: hepatotoxicity; Curative group: hepatotoxicity plus fluid extract of N. albopunctatissimum Lellinger; Standard group: hepatotoxicity plus silymarin; Preventive group: Fluid extract of N. albopunctatissimum Lellinger for one week, then hepatotoxicity. Hepatotoxicity was induced with 56% (w / v) ethanol at doses of 7.6 mL / kg p.c every 12 hours for 7 days. Glutamic pyruvic transaminase (GPT) values were determined at baseline, 7 days after induction and 14 days after. A histopathological study of the livers was performed.

Results:

Phytochemical screening revealed the presence of polyphenols, anthocyanidins, saponins, flavonoids and tannins. The preventive and standard groups showed a very significant decrease in serum GPT levels compared to control group (p <0.01), and curative group did so significantly (p <0.05). Histopathological analysis showed in curative group some degenerating hepatocytes, many with normal-looking cytoplasm; the preventive and standard groups presented hepatocytes with normal architecture and some in degeneration, unlike the evident degeneration and necrosis in control group.

Conclusión:

Niphidium albopunctatissimum Lellinger may have hepatoprotective potential against alcoholic toxicity induced in albino rats.

Keywords : Phytochemicals; Liver; Plant extracts; Ethanol.

        · abstract in Spanish     · text in English     · English ( pdf )