SciELO - Scientific Electronic Library Online

 
vol.5 número3Baja implantación de la teledermatología índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


Journal of Negative and No Positive Results

versión On-line ISSN 2529-850X

Resumen

SANCHEZ-MUNIZ, Francisco J; CULEBRAS, Jesús M  y  VICENTE-VACAS, Luis. JONNPR and the research carried out on the way to the Nobel Prize 2019. A personal view on the molecules and the molecular aspects and underlying control mechanisms related to hypoxia and cancer. JONNPR [online]. 2020, vol.5, n.3, pp.246-258.  Epub 28-Sep-2020. ISSN 2529-850X.  http://dx.doi.org/10.19230/jonnpr.3452.

This special article discusses the mechanisms and central aspects related to three molecules: erythropoietin, hypoxia-induced factor (HIF) and von Hippel-Lindau protein (pVHL) that have led after multiple investigations to win the Nobel Prize in Physiology and Medicine 2019 to scientists William G. Kaelin, Gregg L. Semenza and Peter J. Ratcliffe. The molecular mechanisms taking place in a situation of normoxia, hypoxia and pseudohypoxia are indicated. The article ends by pointing out the pharmacological perspectives that the research of these scientists has opened in the field of cancer and many degenerative diseases.

Palabras clave : Nobel Prize; Hypoxia; Normoxia; HIF; VHL; Pharmacological perspectives.

        · resumen en Español     · texto en Español     · Español ( pdf )