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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611

Nutr. Hosp. vol.31 n.6 Madrid Jun. 2015

http://dx.doi.org/10.3305/nh.2015.31.6.8655 

ORIGINAL / Investigación animal

 

Effect of the intake of liquids rich in polyphenols on blood pressure and fat liver deposition in rats submitted to high-fat diet

Efecto de la ingesta de líquidos ricos en polifenoles sobre la presión arterial y de la deposición de grasa hepática en ratas sometidas a dieta rica en grasas

 

 

Teresa Palmisciano Bedê1, Ana Cláudia Pascoal2, Lucas Hauaji Facó3, Eduardo de Salvo Castro3, Vânia Mattoso4, Juliana Furtado Dias5 and *Vilma Blondet de Azeredo6.

1Federal Fluminense University. Emilia Jesus Ferreiro School of Nutrition. Department of Nutrition and Dietetics. Masters student.
2Federal Fluminense University. Emilia Jesus Ferreiro School of Nutrition. Department of Nutrition and Dietetics. Undergraduate research student.
3Great River University (UNIGRANRIO). Undergraduate research student.
4Federal Fluminense University. Emilia Jesus Ferreiro School of Nutrition. Department of Nutrition and Dietetics. Doctorate student.
5Rio de Janeiro Federal State University (UNIRIO). Nutrition School. Departament of Aplicated Nutrition.
6Federal Fluminense University. Emilia Jesus Ferreiro School of Nutrition. Nutrition School. Department of Nutrition and Dietetics, Brazil.

 

 


ABSTRACT

Introduction: seeking better quality of life, the number of studies on functional foods and disease prevention is growing fast. Whole red grape juice (WRGJ) and red wine (RW) stand out, which are rich in polyphenols, showing antioxidant and anti-inflammatory activity.
Objective: to evaluate the effect of WRGJ and RW intake and resveratrol solution (RS) on blood pressure and fat liver deposition of rats fed with high-fat diet.
Material and Methods: during 60 days, 50 Rattus norvegicus Wistar Albino adults were divided into: control group (CG) - balanced diet, hyperlipidic group (HG), red wine group (RWG), grape juice group (JGG) and resveratrol group (RG) - hyperlipidic diet. Feed and water were offered ad libttum to all groups. WRGJ, RW and RS were offered daily to JG, WG and RG, respectively. Blood pressure was measured using tail plestimograph. The animals were anesthetized, sacrificed and the liver was removed, weighed and fat was extracted using Soxhlet extractor.
Results: no difference in weight gain, feed intake, liver weight and diastolic blood pressure among groups was observed. However, systolic blood pressure (mmHg) and liver fat concentration (g%) were lower (p <0.05) in JGG than in HG, WG and RG, but similar to CG.
Conclusions: the daily consumption of WRGJ minimizes the effects of high-fat diet on systolic blood pressure and prevents nonalcoholic fatty infiltration in the liver of animals, which was not observed in the consumption of RW or resveratrol solution.

Key words: Polyphenols. High-fat diet. Blood pressure. Fatty liver. Wistar rats.


RESUMEN

Introducción: en busca de una mejor calidad de vida, crece el número de estudios sobre alimentos funcionales y la prevención de enfermedades. Destacan el jugo de uva roja (JU) y el vino tinto (VT), que son ricos en polifenoles, y tienen efecto antioxidante y antiinflamatorio.
Objetivo: evaluar el efecto de la ingesta de JU, VT y solución de resveratrol (SR) sobre la presión arterial y la deposición de grasa hepática en ratas alimentadas con una dieta rica en grasas.
Métodos: durante 60 días, 50 adultos de Rattus norvegicus Wistar Albino fueron divididos en grupos: control (GC) - dieta equilibrada y hiperlipídica (GH), vino tinto (GV), jugo de uva (JV) y resveratrol (GR) - dieta rica en grasas. El alimento y el agua se ofrecieron ad libttum a todos los grupos. JU, VT y SR se ofrecen diariamente a la GS, GV y GR, respectivamente. Se midió la presión arterial en la cola mediante manguito inflable. Los animales fueron anestesiados y sacrificados y se les extirpó el hígado, que fue pesado y del cual se extrajo la grasa con el extractor Soxhlet.
Resultados: no hubo diferencia en la ganancia de peso, consumo de alimento, peso del hígado y presión arterial diastólica entre los grupos. Sin embargo, la presión arterial sistólica (mmHg) y la concentración de grasa en el hígado (g%) fueron menores (p <0,05) en los GJ que en GH, GV y GR, pero similar a la GC.
Conclusiones: el consumo diario de JU minimiza los efectos de la dieta alta en grasas en la presión arterial sistólica y previene la infiltración grasa no alcohólica en el hígado de los animales, que no se observó en el consumo de VT o resveratrol aislado en solución.

Palabras clave: Polifenoles. Dieta rica en grasas. Presión arterial. Hígado graso. Ratas Wistar.


 

 

http://scielo.isciii.es/pdf/nh/v31n6/27originalinvestigacionanimal01.pdf

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