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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611

Nutr. Hosp. vol.32 n.1 Madrid Jul. 2015

http://dx.doi.org/10.3305/nh.2015.32.1.9066 

ORIGINAL / Pediatría

 

Amino acid levels in children with celiac diseases

Niveles de aminoácidos en niños con enfermedad celíaca

 

 

Eylem Sevinc1, H. Haluk Akar2, Nergiz Sevinc3, Duran Arslan1, Gülten C. Sezgin4 and Mustafa Kendirci5

1Department of Pediatric Gastroenterology, Erciyes University Faculty of Medicine, Kayseri.
2Department of Pediatric Allergy, Erciyes University Faculty of Medicine, Kayseri.
3Department of Public Health, Erciyes University Faculty of Medicine, Kayseri.
4Department of Gastroenterology, Erciyes University Faculty of Medicine, Kayseri.
5Department of Pediatric Metabolism, Erciyes University Faculty of Medicine, Kayseri, Turkey.

 

 


ABSTRACT

Background & aim: plasma amino acid levels may show differences in regard to physiological changes, diet and diseases. The aim of the study is to measure the amino acid levels in children with celiac disease and compare them with the controls.
Material and methods: sixty-two children with classic celiac disease and 62 age and sex matched healthy control were enrolled in this study. Plasma amino acid levels of the children were measured by using tandem mass spectrometry.
Results: celiac children had significant lower plasma levels of citrülline, glutamine and cystine than control (p<0.05). The alanine, asparagine, glutamic acid, hydroxyproline, isoleucine, leucine, phenylalanine, proline, serine, threonine and valine were significantly higher in celiac children than in controls (p<0.05). On the other hand there were no significant difference in levels of arginine, argininosuccinate, aspartic acid, glycine, homocysteine, hydroxylysine lysine, methionine, ornithine, tryptophan, tyrosine, histidine levels between celiac children and healthy controls (p>0.05).
Conclusions: this study indicated that plasma amino acid levels can be variable in the celiac disease. Further studies with a large number size are needed whether plasma amino acids assays help to reflect of the intestinal mucosal damage and for following compatibility of gluten free diet in the celiac patients.

Key words: Amino acids. Citrulline. Glutamine. Cystine. Celiac disease.


RESUMEN

Antecedentes y objetivo: los niveles de aminoácidos en plasma pueden mostrar diferencias en lo que se refiere a los cambios fisiológicos, la dieta y las enfermedades. El objetivo del estudio es medir los niveles de aminoácidos en los niños con enfermedad celíaca y compararlos con los controles.
Materiales y metodos: en este estudio se inscribieron 62 niños con enfermedad celíaca clásica emparejados por edad y sexo con 62 controles sanos. Los niveles de aminoácidos en plasma de los niños se midieron utilizando la espectrometría de masas.
Resultados: los niños celíacos tenían niveles significativamente inferiores plasmáticos de citrulina, glutamina y cistina que el grupo control (p < 0,05). Alanina, asparagina, ácido glutámico, hidroxiprolina, isoleucina, leucina, fenilalanina, prolina, serina, treonina y valina fueron significativamente mayores en los niños celíacos que en los controles (p < 0,05). Por otro lado, no hubo ninguna diferencia significativa en los niveles de arginina, argininosuccinato, ácido aspártico, glicina, homocisteína, lisina, hidroxilisina, metionina, ornitina, triptófano, tirosina, histidina entre los niños celíacos y los controles sanos (p > 0,05).
Conclusiones: este estudio mostró que los niveles de aminoácidos en plasma pueden ser variables en la enfermedad celíaca. Se necesitan estudios con un tamaño mayor para conocer si los ensayos de aminoácidos en plasma ayudan a reflejar la lesión de la mucosa intestinal y para el seguimiento de la compatibilidad de la dieta libre de gluten en los pacientes celíacos.

Palabras clave: Aminoácidos. Citrulina. Glutamina. Cistina. Enfermedad celíaca.


 

 

http://scielo.isciii.es/pdf/nh/v32n1/21originalpediatria04.pdf

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