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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611

Nutr. Hosp. vol.32 n.3 Madrid Sep. 2015

http://dx.doi.org/10.3305/nh.2015.32.3.9315 

ORIGINAL / Cáncer

 

Ingesta dietética y estado nutricional de pacientes oncológicos que inician tratamiento con inhibidores tirosina quinasa

Dietary intake and nutritional status in oncology patients who start treatment with tyrosine kinase inhibitors

 

 

Isabel Higuera-Pulgar1, Almudena Ribed2, M.a Luisa Carrascal-Fabian1, Irene Bretón-Lesmes1, Rosa M.a Romero-Jiménez2, Cristina Cuerda-Compes1, Cristina Velasco-Gimeno1, Miguel Camblor-Álvarez1 y Pilar García-Peris1

1Unidad de Nutrición Clínica y Dietética. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid.
2Servicio de Farmacia. Hospital General Universitario Gregorio Marañón, Madrid (España).

 

 


RESUMEN

Introduccion: la investigacion sobre nuevos antineoplasicos orales sigue avanzando en los ultimos anos mientras que su repercusion sobre la ingesta dietetica y el estado nutricional (EN) no progresa de la misma forma.
Objetivos: evaluar la ingesta dietetica y EN de pacientes que inician tratamiento con inhibidores tirosina quinasa (ITK) y valorar el impacto que tienen sobre ellos.
Metodos: estudio observacional y prospectivo de seis meses en el que se incluyeron pacientes que iniciaban tratamiento con ITK. La ingesta se evaluo con: recuerdo 24 h y cuestionario de frecuencia de consumo. El EN se valoro con: medidas antropometricas y cuestionario de valoracion subjetiva global generada por el paciente (VSGGP); los resultados se compararon con las referencias SENC-semFYC, 2007 y Moreiras O., 2013. Para el analisis estadistico se utilizaron: Test de Friedman, χ2, Wilcoxon, Kruskall-Wallis y Mann-Whitney. Significacion p<0,05.
Resultados: se incluyeron 22 pacientes (54,5% hombres). Al inicio del tratamiento, el 73,9% tenia un EN adecuado segun VSG-GP. No se produjeron perdidas de peso significativas, pese a que un porcentaje elevado no cubrio los requerimientos energeticos y proteicos. El numero de comidas se relaciono positivamente con la ingesta calorica. La ingesta y los patrones de frecuencia de consumo por grupos de alimentos tampoco variaron durante el tratamiento.
Conclusion: la ingesta dietetica al inicio del tratamiento no alcanza los requerimientos nutricionales. Los ITK no parecen afectar la ingesta ni el estado nutricional de los pacientes. El estudio de estos parametros antes de comenzar el tratamiento evitaria futuras complicaciones y guiaria el consejo dietetico.

Palabras clave: Ingesta dietética. Estado nutricional. Patrones dietéticos. Antineoplásico oral.


ABSTRACT

Background: in recent years, researching about new oral antineoplastics has progressed while its impact on dietary intake and nutritional status (NS) hasnft developed enough yet.
Objectives: dietary intake and NS assessment in patients who start treatment with tyrosine kinase inhibitors (TKI) and evaluate its impact on them.
Methods: an observational, prospective-six-months study, in which were included patients starting treatment with TKI. The intake was evaluated by a 24 h dietary record and a food frequency questionnaire. The NS was evaluated by anthropometric measurements and the patient-generated Global Subjective Assessment (PG-GSA); the results were compared with the Spanish references (SENC-semFYC, 2007 and O. Moreiras, 2013). Friedman test, χ2, Wilcoxon, Kruskal-Wallis and Mann-Whitney were used in the statistical analysis. Significance p<0.05.
Results: 22 patients (54.5% male) were included. At baseline, NS was adequate in 73.9% of patients according PG-GSA. Weight loss was no significant, although a high percentage of the energy and protein requirements hadnLt been reached. The caloric intake was positively related with the number of meals. Dietary habits did not change during treatment.
Conclusion: dietary intake did not reach nutritional requirements at baseline. The TKI donLt seem to affect the patientLs intake and nutritional status. The research about these parameters before starting treatment could prevent future complications and it would guide the dietary advice.

Key words: Dietary intake. Nutrition status. Dietary patterns. Antineoplastic agent.


 

 

http://scielo.isciii.es/pdf/nh/v32n3/32originalcancer02.pdf

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