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Nutrición Hospitalaria

On-line version ISSN 1699-5198Print version ISSN 0212-1611

Nutr. Hosp. vol.32 n.4 Madrid Oct. 2015 

ORIGINAL / Síndrome metabólico


Correlation of serum vitamin D level with type 1 diabetes mellitus in children: a meta-analysis

Correlación de los niveles de vitamina D en suero y la diabetes mellitus tipo 1: un metaanálisis



Changwei Liu1, Mi Lu2, Xiaona Xia1, Jingwen Wang1, Yuanyuan Wan1, Lianping He3 and Mei Li1

1Nanjing Children's Hospital Affiliated to Nanjing Medical University (Nanjing), Jiangsu.
2School of Medical Imaging and laboratory, Wannan Medical College (Wuhu), Anhui.
3School of Public Health, Wannan Medical College (Wuhu), Anhui. China.




Objective: to assess the relationship between serums vitamin D level and type 1 diabetes mellitus (T1DM) in children.
Methods: the following electronic databases were searched until Sep 2014 to identify relevant studies that assessed the relationship between serum vitamin D with T1DM: PubMed\EMbase\Medline\Central Register of Controlled Trials\CBM\Chinese National Knowledge Infrastructure (CNKI)\wangfang; The NOS scale was used to evaluate the quality of studies, and the statistical tests were performed by Stata 11.0 software.
Result: a total of 10 studies were included in this study. Our results showed that serum vitamin D was significantly lower in children with T1DM than in healthy controls (MD = -0.60, P < 0.05). No evidence support publication bias in present study.
Conclusion: the meta-analysis suggests that serum vitamin D level is associated with T1DM in children.

Key words: Serum vitamin D. T1DM. Meta-analysis.


Objetivo: evaluar la relación entre sueros de vitamina D y la diabetes mellitus tipo 1 (T1DM) en niños.
Métodos: fueron utilizadas las siguientes bases de datos electrónicas hasta septiembre de 2014 para identificar los estudios que evaluaron la relación entre la vitamina D y la T1DM: PubMed, EMBASE, MEDLINE, Central Register of Controlled Trials, CBM, China National Knowledge Infrastructure (CNKI), wangfang; las enmiendas a la escala se utilizan para evaluar la calidad de los estudios, y los ensayos estadísticos fueron realizados mediante el software Stata 11.0.
Resultado: fueron incluidos un total de 10 estudios. Nuestros resultados mostraron que los niveles séricos de vitamina D fueron significativamente menores en los niños con T1DM que en los controles sanos (MD = -0,60, P < 0,05). No hay evidencia de sesgo de publicación en el presente estudio.
Conclusión: el metaanálisis sugiere que la vitamina D está asociada con la T1DM en niños.

Palabras clave: Serum de vitamina D. T1DM. Metaanálisis.

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