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versión impresa ISSN 0213-6163
Eur. J. Psychiat. v.21 n.4 Zaragoza oct.-dic. 2007
Neuroleptic malignant syndrome: Possible relationship between neuroleptic treatment and smoking cessation
Mª José Martín Vázquez PhD MPsych*, Teresa Jimeno Beltrán MD**
* Adjunto de Psiquiatría en el Hospital Son Llàtzer
** Hospital Son Llàtzer. SPAIN
We report the case of M., a schizophrenic patient who was treated with high doses of antipsychotics for a long time allowing him to be stable for years. He then decided to give up smoking and two weeks later he suffered a syndrome diagnosed as Neuroleptic Malignant Syndrome with somatic complications. This caused his death two months after the start of the symptoms. We discuss the implications of smoking cessation in the origin of the syndrome due to a lower metabolism of psychotropic medications, which previously had been well tolerated. We conclude that it is important to take into account the smoking and caffeine intake of these patients, as well as other metabolic inductor or inhibitor drugs.
Key words: Neuroleptic malignant syndrome, Smoking cessation, Drug metabolism, Electroconvulsive therapy, Atypical neuroleptic malignant syndrome.
Neuroleptic malignant syndrome (NMS) is a rare, unpredictable, and potentially lethal disease that results from the adverse side effects of antipsychotic medication. Currently, there is no satisfactory treatment available. Modern therapy is halting neuroleptic and anticholinergic treatment, vital support, and medical treatment with bromocriptine, dantrolene, amantadine, benzodiazepines or L-Dopa1,2,3. Some studies suggest that Electroconvulsive therapy (ECT) can be effective in severe, or treatment resistant, NMS. A response to ECT usually appears after a mean of six sessions4,5 although this is unpredictable.
We present the case of M., 38 years old, diagnosed with paranoid schizophrenia beginning at 17 years old. He had several psychiatric hospitalizations, during the nine years prior to the actual episode. Over the last two years, this patient, who received a consistent psychotropic treatment which included: risperidone 3 mg/day, injectable risperidone 100 mg/15 days, olanzapine 10 mg/day, topiramate 600 mg/day and lithium carbonate 800 mg/day, was clinically stable. He previously smoked 80 cigarettes / day but two weeks before he was admitted at hospital he had stopped. He had no additional pathologic antecedents. Previous analyses were performed to control lithium treatment, with lithemias between 1 (two years before this episode) and 0.7 mEq/l (level three months before and at the emergency room), being the rest of biochemical and blood analyses in the normal range. Another drug and creatine phosphokinase levels were not solicited before hospital admission.
M. was admitted to the emergency room with a fever and complaints of not feeling well. As his conditioned worsened in few hours he became comatose (Glasgow 6), without neurological focalized deficit and was in a hypotonic state after sedation; stiffness was not evaluated when he arrived to emergency room, and muscular tone was only considered when the patient was in coma. Other symptoms were sweating, dyspnoea, tachipnoea, tachycardia, and a body temperature of 42.3ºC. He was subsequently admitted to the ICU. His condition was apparently induced by working in a moderately hot environment (30-32ºC).
In the ICU, where he was admitted with a Glasgow 2, blood analysis, EEG, cranial CAT and MRI scan, and lumbar puncture were performed; viral, neurodegenerative, epileptic status, cerebral vasculopathy and autoimmune illnesses were ruled out. The only altered parameters were low level plasma platelets and high CPK (4026 U/l) levels. Levels of CPK were not analysed before emergency room admission. During the first week his level of consciousness slightly improved, but he was still confused, requiring high doses of sedation.
Among the differential diagnoses, heat stroke and neuroleptic malignant syndrome (NMS) were most probable. Topiramate can be a predisposing factor of heat stroke due to reduced transpiration and inhibition of carbonic anhydrase6, while lithium carbonate treatment is a risk factor to develop a NMS7. One major sign of NMS, rigidity, was not apparent in this patient probably due to sedation. However, two other major criteria (hyperthermia, augmentation of CPK) and more than three minor criteria (tachycardia, tachypnoea, alteration of consciousness) of NMS were present. The patient did not respond to the usual heat stroke treatment. He was then treated with electrical convulsive therapy. After ten sessions (parameters: 1.4 msec, 800 mA, 1.5 seg, and 90 Hz, three sessions per week) the patient's neurological state did not improve and treatment was discontinued.
During ICU hospitalization, the patient´s physical state was complicated by a left lung infection due to atelectasia with hypoxemia. Even after hyperthermia, renal function, liver function, and platelet levels returned to normal values. Neurological damage persisted, with oscillations of consciousness and collaboration. During hospitalization, an axonal polyneuropathy developed in the patient with a flaccid paraparesia.
He was discharged of ICU with normalization of vital signs, but the polyneuropathy persisted and he could not speak well due to the prolonged intubation, his consciousness was fluctuating, though no psychotic symptoms were observed. Two months after discharge from the ICU, during his hospital stay the patient suffered a psychotic episode and was treated with benzodiazepines and olanzapine. After this treatment he presented with pneumonia and two weeks later he died in the ICU from complications of the pneumonia and polyneuropathy.
The pathogenesis of NMS is unknown but may be due to a blockage of dopaminergic receptors in hypothalamus (alterations of thermoregulation and vegetative nervous system) and in nigroestriatal track (parkinsonism like rigidity and tremor). Other neurotransmitters like GABA, adrenaline, serotonin, and acetylcholine appear to be related to this syndrome directly or indirectly1,2,8. Although NMS is an idiosyncratic reaction; it more likely occurs with neuroleptics that have a strong effect upon the D2 receptor (like haloperidol) than with neuroleptics that have minor antipsychotic powers.
If rigidity and hyperthermia are absent the diagnosis is questionable, but NMS with minor hyperthermia and rigidity are described as being related to atypical antipsychotic drugs8-13. NMS must be considered in the differential diagnosis of every patient receiving neuroleptic treatment who presents a fever of unknown origin with or without muscular rigidity14. Biochemical alterations present in NMS are not specific, it is frequent the presence of leukocytosis, CPK augmentation, hydroelectrolyte alteration (hyperlkaliemia, metabolic acidosis, and hypocalcaemia), and moderate increases in hepatic transaminases; they are not useful for diagnosis but may be used to evaluate severity of syndrome1,3,15-17.
Patients with schizophrenia are more likely to have a higher rate of nicotine use and more likely to smoke high-tar cigarettes than the general population or patients with other psychiatric diagnosis18-20. Tobacco smoking seems to act upon cytochrome CYP1A2, inducing neuroleptic metabolism, mainly on clozapine and olanzapine, and polymorphisms within the variation in the cytochrome P450, frequent for isoenzyme 1A2, may influence drug-induced adverse effects and drug efficacy21. Several studies suggest that smokers need higher levels of antipsychotics than non-smokers22-24. Smoking can lower the blood levels of some antipsychotics by as much as 50%. Neuroleptic toxicity can appear two-to-four weeks after smoking cessation22. This effect may be related to the lack of metabolic induction by smoking23. In addition, this effect may be less important upon metabolism of risperidone and aripiprazole (CYP2D6 (nicotine could compete with risperidone because the two of them are metabolised with this isoenzyme) and CYP3A, quetiapine (CYP3A) and ziprasidone (CYP3A and an aldehyde oxidase). On the other hand, caffeine is metabolized by CYP1A2 like neuroleptics and changes in its intake can change the plasma concentration of the drug because of enzyme competition23.
Nicotine increases mesolimbococortical dopaminergic activity in the nucleus accumbens and the prefrontal cortex25,26. This dopamine stimulation could explain its use as a form of self-medication to reduce negative, cognitive and affective symptoms and could explain the strong smoking habit of schizophrenic patients25-28, though this effect has not been replicated in consistent studies. And smoking quitting has not probe to worsen the disability in schizophrenia26. In some studies the smoking group of schizophrenia patients demonstrates less akathisia, but not in all of them 25,28,29. In patients with schizophrenia, smoking cessation is more likely to bring about problems, than compared with the general population.
In this patient, the NMS could have resulted from both physical and metabolic factors. The physical factors could have included working in a warm place in summer, physical exercise, and reduced sweating because of topiramate treatment. The main metabolic confounding factor was the slow-down of neuroleptic elimination, mainly olanzapine, because the lack of enzymatic induction due to recent smoking cessation. Other factors that could contribute to the development of the syndrome were topiramate treatment associated with neuroleptics, which increases the danger of heat stroke if hypothalamus deregulation occurs, extended treatment with high doses of neuroleptics, and smoking cessation that could have aggravated previously stable plasma drug levels.
In patients receiving several treatments that result in complex metabolic profile, adding the adverse effects and mechanisms of external agents like salt, smoking, or caffeine intake can alter neuroleptic plasma levels leading to potentially lethal adverse effects. This must be considered when a patient decides to change some habits or received another drug and drug levels should be performed.
1. Bhanushali MJ. The evaluation and management of patients with neuroleptic malignant syndrome. Neurol Clin 2004; 22 (2): 389-411. [ Links ]
2. Ebadi M, Pfeiffer RF, Murrin LC. Pathogenesis and treatment of neuroleptic malignant syndrome. Gen Pharmacol 1999; 21 (4): 367-386. [ Links ]
3. Susman VL. Clinical management of neuroleptic malignant syndrome. Psychiat 2001; 72 (4): 325-336. [ Links ]
4. Ozer F. Electroconvulsive therapy in drug-induced psychiatric states and neuroleptic malignant syndrome. J Ect 2005; 21 (2): 125-127. [ Links ]
5. Trollor JN, Sachdev PS. Electroconvulsive therapy of neurolpetic malignant syndrome: a review and report of cases. Aus N Z J Psychiat 1999; 33 (5): 650-659. [ Links ]
6. Ben-Zeev B, Watemberg N, Augarten A, Brand N, Yahav Y, Efrati O, Topper L, Blatt I. Oligohydrosis and Hyperthermia: Pilot Study of a Novel Topiramate Adverse Effect. Journal Child Neurology 2003; 18 (4): 254-258. [ Links ]
7. Chandran GJ, Mikler JR, Keegan DL. Neuroleptic malignant syndrome: case report and discussion. Canadian Medical Association Journal 2003; 169 (5): 439-442. [ Links ]
8. Gurrera RJ. Sympathoadrenal hyperactivity and the etiology of neuroleptic malignant syndrome. Am J Psychiat 1999; 156: 169-180. [ Links ]
9. Ananth J, Parameswaran S, Gunatilake S, Burgoyne K, Sidhom T. Neuroleptic malignant syndrome and atypical antipsychotic drugs. J Clin Psychiat 2004; 65: 464-470. [ Links ]
10. Nielsen J, Bruhn AM. Atypical neuroleptic malignant syndrome caused by olanzapine. Acta Psychiat Scand 2005; 112: 238-240. [ Links ]
11. Atbasoglu EC, Ozguven HD, Saka MC, Goker C. Rhabdomyolisis and coma associated with amisulpride: a probable atypical presentation of neuroleptic malignant syndrome (letter) J Clin Psychiat 2004; 65 (12): 1724-1725. [ Links ]
12. Hasan S, Buckley P. Novel antipsychotics and the neuroleptic malignant syndrome: a review and critique. Am J Psychiat 1998; 155 (8): 1113-1116. [ Links ]
13. Matsumoto R, Kitabayashi Y, Nakatomi Y, Tsuchida H, Ukui K. Neuroleptic malignant syndrome induced by quetiapine and fluvoxamine. (letter) Am J Psychiat 2005; 162 (4): 812. [ Links ]
14. Hall R, Appleby B Hall R. Atypical Neuroleptic Malignant Syndrome presenting as fever of unknown origin in the elderly. South Med J 2005; 98 (1): 114-117. [ Links ]
15. Mendhekar DN. Neuroleptic malignant syndrome precipitated by haloperidol following clozapine discontinuation. Aust N Z J Psychiat 2005; 39 (10): 947-8. [ Links ]
16. Simon HB. Current concepts: hyperthermia. N Eng J Med 1993; 329 (7): 483-487. [ Links ]
17. Litman RS, Rosenberg H. Malignant Hyperthermia: update on susceptibility testing. JAMA 2005; vol 293: 2918-2924. [ Links ]
18. Lyon ER. A review of the effects of nicotine on schizophrenia and antipsychotic medications. Psychiat Serv 1999; 50: 1346-1350. [ Links ]
19. McEvoy JP Allen TB. Substance abuse (including nicotine) in schizophrenic patients. Curr Opin Psychiat 2003; 16: 199-205. [ Links ]
20. Weiser M, Reicherberg A, Grotto I, Yasvitzky R, Rabinowitz J, Lubin G, Nahon D, Knobler HY, Davidson M. Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: a historical-prospective cohort study. Am J Psychiat 2004; 161: 1219-1223. [ Links ]
21. Malhotra AK, Murphy GM, Kennedy JL. Pharmacogenetics of psychotropic drug response. Am J Psychiat 2004; 161 (5): 780-796. [ Links ]
22. Faber MS, Fuhr U. Time response of cytochrome P450 1A2 activity on cessation of heavy smoking. Clin Pharmacol Therapeutics 2004; 76: 178-184. [ Links ]
23. de Leon J. Atypical antipsychotic dosing: the effect of smoking and caffeine. Psychiat Serv 2001; 55 (5): 491-493. [ Links ]
24. Benowitz NL, Peng M, Jacob P. Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism. Clin Pharmacol Therapeutics 2003; 74: 468-474. [ Links ]
25. Barnes M, Lawford BR, Burton SC, Heslop KR, Noble EP, Hausdorf K, Young RM. Smoking and schizophrenia: is symptom profile related to smoking and which antipsychotic medication is of benefit in reducing cigarette use? Aust N Z J Psychiat 2006; 40 (6-7): 575-580. [ Links ]
26. Patkar AA, Gopalakrishnan R, Lundy A, Leone FT, Certa KM, Weinstein SP. Relationship between tobacco smoking and positive and negative symptoms in schizophrenia. J Nerv Ment Dis 2002; 190: 604-610. [ Links ]
27. Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J. et al, Proof-of-concept trial of an a7 nicotine agonist in schizophrenia. Arch Gen Psychiat 2006; 63: 630-638. [ Links ]
28. Menza MA, Grossman N, Van Horn M, Cody R, Forman N. Smoking and movement disorders in psychiatric patients. Biol Psychiat 1991; 30 (2): 109-115. [ Links ]
29. de Leon J, Diaz FJ, Aguilar MC, Jurado D, Gurpegui M. Does smoking reduce akathisia? Testing a narrow version of the self-medication hypothesis. Schizo Research 2006; 86 (1): 256-268. [ Links ]
Dra. Mª José Martín Vázquez
Dirección: Hospital Son Llàtzer Departamento de Psiquiatría
Crta Manacor, km. 4 07198-Palma de Mallorca Baleares
Tfno: 871202000, ext 1439 // 639391660
Dra. Teresa Jimeno Beltrán
Dirección: Hospital Son Llàtzer Departamento de Psiquiatría
Crta Manacor, km. 4 07198-Palma de Mallorca Baleares
Tfno: 871202000, ext 1439 // 639391660
Received 20 April 2007
Revised 24 July 2007
Accepted 29 August 2007