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versión impresa ISSN 1130-0108
Rev. esp. enferm. dig. vol.103 no.8 Madrid ago. 2011
Gastric polyps: analysis of endoscopic and histological features in our center
Pólipos gástricos: análisis de características endoscópicas e histológicas en nuestro medio
Francisco Javier García-Alonso, Rosa María Martín-Mateos, Juan Ángel González-Martín, José Ramón Foruny, Enrique Vázquez-Sequeiros and Daniel Boixeda de Miquel
Department of Gastroenterology. Hospital Universitario Ramón y Cajal. Madrid, Spain
Background and objective: the prevalence of gastric polyps in esophagogastroduodenoscopies (EGDs) ranges between 0.33 and 6.35%. The relative frequency of histological subspecies varies widely among published series. The objective is to describe the endoscopic and histological characteristics of the polypoid lesions, and to study possible associations.
Material and methods: we retrospectively revised the EGDs done in our center in 2009. Demographic, endoscopic and histological data were gathered. We proceeded to a descriptive analysis and studied possible associations.
Results: gastric polypoid lesions were found in 269 of the 6,307 (4.2%) reviewed EGDs, 61% were found in women. Mean age was 64.93 years (SD: ±15.23). A single polyp was found in 186 patients (69.1%), over 10 lesions appeared in 31 (11.5%). An estimated size of ≤ 3 mm was found in 108 lesions (37.2%) and greater than 10 mm in 52 cases (17.9%). Most lesions were sessile (90.8%). The location of 34.8% was the gastric antrum, 39.3% were found in the gastric body and 25.9% were in the fundus. Chronic gastritis was confirmed in 53.5% of the patients and 46.5% had received PPIs. Histopathological diagnosis was: hyperplastic polyps 50.9%, fundic gland polyps 7.4%, adenomas 3%, adenocarcinomas 1.9% and normal mucosa 29.7%. We found no significant association between the histopathological type of lesions and the use of proton pump inhibitor.
Conclusions: we found polypoid lesions in 4.2% of the EGDs. The most frequent histopathological findings were hyperplastic polyps (50.9%), followed by fundic gland polyps (7.4%), adenomas (3%), and adenocarcinomas (1.9%).
Key words: Polyps. Gastric mucosa. Proton pump inhibitors.
Antecedentes y objetivo: la prevalencia de pólipos gástricos en la endoscopia digestiva alta (EDA) oscila entre el 0,33 y el 6,35%. La frecuencia de los subtipos histológicos varía ampliamente entre las series publicadas. El objetivo de nuestro estudio es describir las características endoscópicas e histológicas de los pólipos hallados en las EDA y valorar posibles asociaciones.
Material y métodos: revisamos retrospectivamente las EDA realizadas en nuestro centro en 2009. Se recogieron variables demográficas, endoscópicas e histológicas. Se realizó un análisis descriptivo y se estudiaron posibles asociaciones.
Resultados: se analizaron 6.307 EDA identificándose lesiones polipoideas en 269 (4,2%), el 61% en mujeres. La edad media fue de 64,93 años (DE: ±15.23). En 186 pacientes (69,1%) se objetivó un solo pólipo y en 31 (11,5%), más de 10. Se estimó un tamaño ≤ 3 mm en 108 lesiones (37,2%), y mayor de 10 mm en 52 casos (17,9%). La mayoría de los pólipos eran sésiles (90,8%). El 34,8% se ubicaban en antro, el 39,3% en cuerpo y el 25,9% en fundus. El 53,5% de los pacientes presentaba gastritis crónica y el 46,5% había recibido inhibidores de la bomba de protones (IBP). Los hallazgos histológicos principales fueron: pólipos hiperplásicos 50,9%, pólipos de glándulas fúndicas 7,4%, adenomatosos 3% y adenocarcinomas 1,9%. En el 29,7% la biopsia mostró una mucosa normal. No se objetivó asociación entre el tipo histológico y el consumo de IBP.
Conclusiones: encontramos lesiones polipoideas en el 4,2% de las EDA. La histología relevante más frecuente fueron pólipos hiperplásicos (50,9%), de glándulas fúndicas (7,4%), adenomas (3%) y adenocarcinomas (1,9%).
Palabras clave: Pólipos. Mucosa gástrica. Inhibidores de la bomba de protones.
The incidental finding of gastric polyps during the course of a routine endoscopy is an increasingly common fact (1). It has been estimated that these types of polyps appear in 0.33-6.35% of esophagogastroduodenoscopies (EGDs) (2).
Gastric polyps classification is based on its histological features, and based on that, we can differentiate two important groups: neoplastic and benign polyps. The second group is the most common (3), and among them we may find several subtypes such as hyperplastic or fundic glands polyps. The prevalence of each of these subgroups widely varies depending on the population studied.
There are no specific symptoms related to the presence of gastric polyps. Although more frequently they are asymptomatic, sometimes they may present with gastrointestinal bleeding, anemia or delayed gastric emptying (4).
Gastric polyps may occur in a number of congenital syndromes such as familial adenomatous polyposis, juvenile polyposis or Peutz-Jeghers syndrome, but more often we find them sporadically, constituting an incidental finding.
The aim of our study was to describe the endoscopic and histological features of gastric polyps found in our patient-population. The secondary aim of the study was to assess the relationship between the use of proton pump inhibitors (PPIs) and the presence of fundic glands polyps on EGDs.
Patients and methods
This study was designed as a retrospective analysis of upper gastrointestinal endoscopies (EGDs) performed at Ramón y Cajal Hospital, Madrid, between January 1 and December 31, 2009. For this purpose, all endoscopy reports of explorations carried out during this period of time were reviewed. We included both scheduled endoscopies and emergency procedures. We only excluded from analysis those patients who had been previously included in the study.
Data were obtained from endoscopy reports, electronic medical records (contained on "CAJAL computer database") and, in some cases, by telephone interview. The following information was collected: age, sex, number of gastric polyps found, morphology, size and location. Polyp size was estimated by comparing with the size of biopsy forceps in those polyps that were just biopsied or according to the size reported on the pathologist's report after endoscopic polypectomy. Histologic features, presence of associated chronic gastritis and infection by H. pylori were collected from pathology reports consulted in electronic medical records. The prior use of PPI was established through medical records and, in some cases, where this information was not clearly stated, telephone interviews were conducted. We defined prior use of PPI when it was prescribed for more than 3 months. The protocol was approved by the Clinical Research Ethics Committee (CREC) of our Hospital.
Statistical analysis was performed with the SPSS program (version 15.0). Continuous variables were described using mean and standard deviation (SD), discrete ones using percentages. The significance of possible associations between discrete variables was evaluated by c2 test of Pearson.
Six thousand three hundred and seven endoscopies were analyzed, identifying 269 images suggestive of polyps (4.2%).
Sixty-one percent of polyps were found in women, and the remaining 39% in men. Mean age was 64.93 years (SD: ±15.23).
Regarding the number of polyps found in each patient, 186 cases (69.1%) presented a single polyp, 15.3% of patients, presented 2-4 polyps, 4.1% had 5 to 10 polyps and 11.5 %, had more than 10 polyps.
Most polyps were sessile (90.8%), and only 9.2% were pedunculated. A total of 34.8% were located in the antrum, 39.3% in the body and 25.9% in the fundus of the stomach. Regarding size, it was estimated a size < 3 mm in 108 lesions (37.2%), and larger than 10 mm in 52 (17.9%). The rest, 26.9% and 17.9% were described with an approximate size of 3-5 and 5-10 mm, respectively (Table I).
Besides the polyp related features, other issues were also evaluated. H. pylori infection was diagnosed in 20.8% of patients, in 72.1% no bacilli were found in the histological samples and in 7.1% of cases infection was not investigated.
The chronic use of PPIs was observed in 46.5% of patients, while 46.8%, reported no use of PPIs. Definitive data could not be obtained in 6.7% of cases. Chronic gastritis was histologically demonstrated in 53.5% of patients, in 39.8% of samples, histology was not consistent with gastritis, and this information could not be answered from reports in 6.7% of cases (Fig. 1).
Histologically, 50.9% of polyps were hyperplastic, 7.4% were fundic gland polyps, 3% were adenoma and 1.9% adenocarcinoma. In the remaining 4.8%, lipomas, GIST, xanthomas and inflammatory pseudopolyps were found (Fig. 2). In 80 patients (29.7%) gastric specimens identified endoscopically as polyps were described as normal gastric mucosa.
We evaluated the potential association between fundic gland polyps and long-term treatment with PPIs. Among 20 patients with fundic gland polyps, PPI intake could only be investigated in 19 of them; 57.9% of them reported previous treatment, while in non fundic gland polyps chronic use of PPI was evidenced in 49.1%, a difference not statistically significant (p = 0.463)
The body of literature on gastric polyps shows wide variations regarding the prevalence of different histological subtypes.
The largest series of EGDs to date was published by Carmack et al. in 2009 (12), including over 120,000 patients and finding lesions labeled as nodules, polyps or masses in 6.35% of them. Sixteen percent of them did not meet histopathological criteria for any polypoid or neoplastic lesion. Fundic gland polyps were the most frequent diagnosis, representing 77% of all gastric polyps. Hyperplastic polyps and foveolar hyperplasia were found in 17% of patients. Adenoma, carcinoid tumor, pancreatic heterotopia, xanthoma, lipoma, GIST, leiomyoma, inflammatory fibroid polyp and lymphoma were found in less than 1% of lesions. There was no statistically significant association between H. pylori infection and any histological subtype. Conversely, both fundic gland and hyperplastic polyps were most frequently found in not infected patients.
Over 26,000 EGDs were included in the work by Morais et al. published in 2007 (13). Polyps were found in only 0.6% of them. Hyperplastic polyps were the most frequent subtype, 71.3%, while fundic gland polyps and adenomas appeared in 16.3 and 12.4% respectively. Two percent of polyps were adenocarcinomas. Lesions endoscopically suggestive of polyps without histological correlation were not included in the analysis.
A study on pediatric population found polypoid lesions in 45 out of 5,766 EGDs. No histological diagnosis of polypoid or neoplastic lesion was achieved in 11% of them, 42% were hyperplastic polyps, 40% fundic gland polyps and 5% adenomas.
The relative prevalence of different subtypes found in series with patients from nearer geographical areas resemble our results. The presence of hyperplastic polyps ranges between 44.5 and 68% of lesions and fundic gland polyps between 9 and 14% (15-17).
We have found only one single study on Spanish population, including 5,314 EGDs (18). Polypoid lesions were found in 0.33% of patients but 37.5% of them did not meet criteria of polyp or neoplastic lesions. Hyperplastic polyps included 46.9% of specimens, 12.5% were adenomas and 3.1% adenocarcinomas.
There is a significant difference in the prevalence of histological subtypes among the published series (Table II). These discrepancies suggest a possible relationship between certain histological kinds and the geographical location of the population included, which may be due to demographic, genetic or socioeconomic characteristics. Further studies are required to disclose these possible associations.
A remarkable 29.7% of our patients had no evidence of polyp or neoplastic lesion on histological examination. A deeper analysis showed that 43.7% of these were < 3 mm (71.2% under 5 mm). The proportion of lesions without a significant histological diagnosis is similar to the 37.5% reported by Macenlle et al. (18) but higher than in the study published by Carmack (16%) (12).That study reported that 79.1% of lesions according to their endoscopic appearance were < 5 mm while the latter offered no size stratified analysis. Data on the proportion of specimens without a significant histological diagnosis is not included on other published series or remains low, as in the pediatric patients by Attard et al. (11%) (14). Based on these data, one may arrive that smaller lesions have higher chances to lack a histological diagnosis.
In our series, 32.8% of specimens < 3 mm displayed no significant histological correlate, while this only appeared on 18.3% of lesions over 10 mm. Considerable discrepancy in histologic findings between endoscopic forceps biopsies and resected specimens has been published in other series (19).
The association between hyperplastic polyps and H. pylori infection is still uncertain, with studies offering data for (20,21) and against it (12,22). There are many potential sources for bias in our study (retrospective study design, PPI at the time of endoscopy in 46.5% of patients, use of histology as the only method to address the presence of H. pylori without further knowledge of the location and number of the biopsies taken) to consider them an appropriate source to study this association.
A relationship between PPIs and fundic gland polyps has not yet been fully established. Jalving et al. published a study including 599 patients, 322 of them on PPI (23). Fundic gland polyps were observed in 107 patients, 75 on PPIs and 32 untreated. A significant association was found only in the subgroup of patients treated for over 1 year. A retrospective study by Vieth offered opposite results. A cohort of 2,251 patients with no H. pylori infection and on PPI for at least 1 week was compared to a control group including 28,096 patients without H. pylori infection. No significant association was found, as both groups had a similar prevalence of fundic gland polyps (5.0% with PPIs and 5.2% without them). Although these papers may suggest a possible association with long term treatment, our data do not support a relationship between PPI and fundic gland polyps. We established that treatments over 3 months were considered as long term treatment with PPI and therefore we cannot exclude that a larger interval might have found a significant association.
In summary, we report a series of over 6,300 EGDs presenting gastric polyps in 4.2% of them. Hyperplastic polyps were the most frequent (50.9%) followed by fundic gland polyps (7.4%). We found no significant association between PPI intake and any histological kind of polyp.
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Francisco Javier García Alonso.
Department of Gastroenterology.
Hospital Universitario Ramón y Cajal.
Ctra. Colmenar Viejo, km. 9.100.
28049 Madrid, Spain.