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Revista Española de Enfermedades Digestivas

versión impresa ISSN 1130-0108

Rev. esp. enferm. dig. vol.103 no.11 Madrid nov. 2011

http://dx.doi.org/10.4321/S1130-01082011001100011 

CARTAS AL DIRECTOR

 

Not only aondyloma acuminata of the anal canal: a rare case with coexisting adenocarcinoma

No solo condyloma acuminata del canal anal: un rara caso coexistiendo con adenocarcinoma

 


Key words: Condyloma acuminata. Anal canal. Malignancy. Adenocarcinoma.


 

Dear Editor,

A 38-year-old homosexual male presented to our hospital with a two-week history of foreign body and itching sensation in the anus. There were no changes in his appetite and body weight. In his medical history, there is no gastroduodenal ulcer or hematochezia. He was afebrile on admission, and physical examination of abdomen showed no palpable mass or tenderness. There were no palpable inguinal lymph nodes. Laboratory data showed no remarking findings and negative human immunodeficiency virus (HIV). Tumor markers revealed normal carcinoembryonic antigen (CEA) and carbohydrate antigen-199 (CA-199) levels. Digital examination showed multiple exophytic lesions over the anal canal. Anoscopy showed verrucous papules at the anorectal junction and all lesions in clusters of two or three were less than 1 cm in diameter. Excisional biopsy was performed. Histopathologic report indicated a diagnosis of co-existing condyloma acuminata and poorly-differentiated adenocarcinoma of the anal canal without stromal invasion (Fig. 1). In addition, the epithelium showed vacuolization or koilocytosis, characteristic of human papillomavirus (HPV) infection. Colonscopy was performed without abnormal findings and the patient underwent wide excision. The postoperative course was unevenful, and the patient was discharged on the 4th postoperative day. He recovered well without further recurrence of anal cancer or condyloma acuminata at 12 months follow-up.

 

Discussion

Infection with human papillomavirus (HPV) may manifest as anal condyloma and cause clinical symptoms such as burning, itching, bleeding, and pain. In addition, it is a primary risk factor for dysplasia and may progress to squamous cell carcinoma (SCC) of the anus (1). The reported incidence of SCC of the anus in patients with anal condyloma is rare and accounts for only 3 to 4% in the literature (2). However, the natural history of progression from benign anal condyloma to anal squamous intraepithelial lesions and SCC is not well defined (3). Since anal cancer is only 2% of all colorectal malignancy, adenocarcinoma of anal canal is even rare and constitutes about 5% of anal malignancy (4). There are only few reports in correlation with adenocarcinoma of anal canal, including anal fistula, hemorrhoids, ulcerative colitis, or Crohn's disease (5-7). Although adenocarcinoma of the anal canal is rare with limited data regarding treatment and outcomes, Beal et al. (8) suggested that the abdomino-perineal resection (APR) for invasive adenocarcinoma of anal canal was a reasonable approach.

To the best of our knowledge, this case is not yet reported in the literature, especially with such presentation of co-existing adenocarcinoma and condyloma acuminata over the anal canal. For unknown lesions of anal canal, biopsy and histological examination are importantly required to prove the malignancy and grade dysplasia. In addition, further endoscopic studies are suggested for monitoring after operation.

 

Chin-Ta Lin1, Ying-Yu Lee1, Chao-Yang Chen1, Chang-Chieh Wu1,
Jong-Shiaw Jin2 and Shu-Wen Jao1*

1Division of Colon and Rectal Surgery. Department of Surgery.
Tri-Service General Hospital. National Defense Medical Center.
Taipei, Taiwan. Republic of China.
2Department of Pathology. Tri-Service General Hospital.
National Defense Medical Center. Taipei, Taiwan. Republic of China

 

References

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3. Colquhoun P, Nogueras JJ, Dipasquale B, et al. Interobserver and intraobserver bias exists in the interpretation of anal dysplasia. Dis Colon Rectum 2003;46:1332.         [ Links ]

4. Deans GT, McAleer JJ, Spence RA. Malignant anal tumours. Br J Surg 1994;81:500-8.         [ Links ]

5. Timaran CH, Sangwan YP, Solla JA. Adenocarcinoma in a hemorrhoidectomy specimen: case report and review of the literature. Am Surg 2000; 66: 789-92.         [ Links ]

6. Chia CS, Chew MH, Chau YP, Eu KW, Ho KS. Adenocarcinoma of the anal transitional zone after double stapled ileal pouch-anal anastomosis for ulcerative colitis. Colorectal Dis 2008; 10: 621-3.         [ Links ]

7. Wong NA, Shirazi T, Hamer-Hodges DW, Corfield AP, Lessells AM. Adenocarcinoma arising within a Crohn's-related anorectal fistula: a form of anal gland carcinoma? Histopathology 2002;40:302-4.         [ Links ]

8. Beal KP, Wong D, Guillem JG, Paty PB, Saltz LL, Wagman R, et al. Primary adenocarcinoma of the anus treated with combined modality therapy. Dis Colon Rectum 2003;46:1320-4.         [ Links ]

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