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Neurocirugía

versión impresa ISSN 1130-1473

Neurocirugía v.16 n.6 Murcia dic. 2005

 

Xanthogranuloma of the choroid plexus of the third ventricle: case report and literature review

P. Miranda; R.D. Lobato; J.R. Ricoy*; A. Lagares y A. Ramos**

Servicios de Neurocirugía, Neuropatología* y Neurorradiología**. Hospital 12 de Octubre. Madrid


Summary

Xanthogranulomas of the choroids plexus (XG) are benign tumours of debatable etiology which become rarely symptomatic. Only few cases have been studied with MRI. A new case of xanthogranuloma of the third ventricle showing unusual features in the CT and MRI studies in a 47-year-old man with a 2-month history of gait and urinary disturbances and cognitive impairment is reported. The literature concerning clinical and neuroradiological presentation of intracranial xanthogranulomas is reviewed.

KEY WORDS: Xanthogranuloma. Third ventricle tumour. MRI


Xantogranuloma del plexo coroideo del tercer ventriculo: descripción de un caso y revisión de la literatura

Resumen

El xantogranuloma del plexo coroideo es un tumor benigno de etiología desconocida que raramente produce síntomas. Su comportamiento en los estudios de resonancia magnética se ha descrito en pocas ocasiones y no está bien definido. Presentamos un nuevo caso de xantogranuloma del tercer ventriculo con caraterísticas atípicas en los estudios de CT y RM craneal en un paciente de 47 años y una clínica de 2 meses de evolución de alteración de la marcha y deterioro cognitivo. Igualmente, se revisa la literatura existente respecto a la presentación clínica y radiológica de estos tumores.

PALABRAS CLAVE: Xantogranuloma. Tumor de tercer ventrículo. RM


Recibido: 20-09 04. Aceptado: 10-01-05

Abbreviations. CT: computarized tomography. XG: xantogranuloma. MRI: magnetic resonance imaging

 

Introduction

XG are benign tumours typically composed of large foam-filled cells with clusters of lymphocytes and macrophages associated to cholesterol clefts. XG rarely cause neurological dysfunction3,13,15. With few exceptions, they constitute incidental autopsy findings almost always restricted to the choroid plexus of the lateral ventricles21. Obstruction of the ventricular system has been reported infrequently. Etiology is still debatable17. We report a new case of symptomatic XG of the third ventricle studied with CT and MRI and showing some particular histopathological and neuroradiological features.

Case report

A 47-year-old man was admitted with a 2-month history of gait instability and urinary disturbances, consisting in occasional loss of sphincterian control and short-term memory deficits. The symptoms had developed insidiously and the patient did not suffer headache, vomiting or loss of visual acuity.

Physical and routine laboratory examinations, including serum cholesterol determinations, were normal. Neurological examination revealed disturbance of recent memory and cognitive impairment. Fundoscopy was normal. He scored 24/30 on minimental test. Short stepped gait and intentional tremor were also observed.

Cranial CT scan showed a 2x2x1 cm oval shaped lesion located in area of the third ventricle obstructing the foramina of Monro and causing biventricular hydrocephalus. The lesion was heterogeneous appearing partly hypodense and hyperdense, with hyperdense areas corresponding to calcification. Following contrast injection the lesion showed partial enhancement. There was associated edema in the basal ganglia of the left cerebral hemisphere (Figure 1).

Figure 1. Preoperative CT scan. A rounded mass in the region of the third ventricle, 
slightly hyperdense with of calcification obstructing the foramina of Monro is seen. 
Surrounding brain edema and obstructive hydrocephalus can also be appreciated.

 

Cranial MRI revealed the lesion in the region of third ventricle and hypothalamic area. It was located mainly extraventricularly, spreading between the fornices, occluding both foramina of Monro and causing bilateral hydrocephalus. It was heterogeneous in appearance being isointense in pT1 sequences and hyperintense in pT2 images, showing haemosiderin deposits and calcification. Important hyperintensity extending into the left basal ganglia region suggestive of edema was also observed. Following gadolinium administration it showed partial enhancement (Figure 2).

The patient was operated through a transcallosal approach. The left foramen of Monro appeared deformated by a brown yellowish subependymal lesion adhered to the body of the left fornix. Total excision preserving both fornices was achieved. Histopathological examination revealed a lesion composed of foamy cells in relation to vascular lines corresponding to choroids plexus showing changes secondary to haemorrhage and fibrosis which would explain the absence of the typical epithelial covering of the choroid plexus. The histological diagnosis was xanthogranuloma (Figure 3).

 

Figure 3. Microphotograps of the tumor showing A) Coalescent papillary structures with clear centers and areas of hemmorrhage and calcification. 
H/E x100; B) Clear papillary structures with foamy cells surrounded by fibrous reaction and inflammatory infiltrates. 
H/E x200; C) Detail of a papillary structure with a central vessel, surrounded by lipid-laden cells. H/E x400.

Postoperative MRI control showed disappearance of perilesional edema and mass effect observed preoperatively (Figure 2 d). Because of moderate neurological deterioration and persistent ventricular enlargement, a medium pressure ventriculoperitoneal shunt had to be implanted. Six months after surgery both gait and memory as well as urinary sphincterian control were normal and the patient returned to his normal daily activities working as a full-time university professor.

Discussion

XG are benign tumours typically composed of cholesterol clefts, macrophages (xanthoma cells), chronic inflammatory cellular reaction and haemosiderin deposits. XG were firstly described by Blumer in 19002 and since then they have been found incidentally in 1.6 to 7% of the cases in autopsy series19. XG are more frequent in the lateral ventricles where they usually remain asymptomatic because they are too small to obstruct the CSF flow. By contrast, those found in the third ventricle are more commonly symptomatic.

Fifteen cases of XG of the lateral ventricles have been reported and the most frequent localization was the glomus of the choroid plexus. Among the sixteen cases of XG located in the third ventricle reported up to date1,6,8,10-15,17,18,20 only four were studied with MRI17,18,20. XG of the fourth ventricle are exceptional19.

Pathogenesis of XG is still a matter of controversy18. Brück et al reviewed the literature and found that all asymptomatic XG and 6 out of 7 symptomatic XG of the lateral ventricles had the typical histological features described above. In contrast, lesions in the third ventricle were often cystic and epithelium-lined, or appeared associated to colloid cysts3. Thus some authors believe that at the origin, a neuroepithelial cyst is formed which may evolve either to a colloid cyst, to a XG or to intermediate forms3,13,14. However, the total absence of epithelial and cystic components as occurred in our patient, has been reported previously18. Inflammatory response to the invagination and proliferation of the choroid plexus may be the pathogenic mechanism in these cases, as it happens in XG of the lateral ventricles5, 21.

These forms of XG of the third ventricle may exhibit higher rates of additional pathological changes, such as inflammatory cell infiltration or intralesional haemorrhage. A primary intracerebral origin unrelated to the epithelium of the choroid plexus of the third ventricle can not be excluded, although this possibility seems much less likely. However, a case of multicentric parenchymal xanthogranuloma in a child has been recently reported and the authors suggested that the lesion had a developmental origin9 . The main histological characteristics of the cases of XG of the third ventricle reported up to date are summarized in Table 1.

In the CT scan studies, XGs of the third ventricle have been found to be oval and smooth walled making them indistinguishable from colloid cysts. In addition, and also like colloid cysts, XG may show different CT densities, varying from hyper-to hypodense in comparison to brain tissue (Table 2). In the four cases of XG of the third ventricle studied with MRI they appeared iso-hyperintense in pT1 and hyperintense in pT2 sequences, probably because of high solid lipidic components15, and they enhanced following gadolinium administration (Table 3). Brain edema related to XG had been previously reported in one case of the lateral ventricles4 but this is the first case of XG of the third ventricle showing associated brain edema demonstrated with MRI.

XG in our patient shows the particularities of being subependymal in location and mainly extraventricular, histologically unrelated to the choroidal epithelium or a colloid cyst, and producing large areas of edema in the basal ganglia. All these factors support a primary origin of the lesion out the third ventricle without apparent relation to a previous neuroepithelial or colloid cyst.

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Miranda, P.; Lobato, R.D.; Ricoy, J.R.; Lagares, A.; Ramos, A.: Xanthogranuloma of the choroid plexus of the third ventricle: case report and literature review. Neurocirugía 2005; 16: 518-522.


Correspondencia postal: P. Miranda. Servicio de Neurocirugía. Hospital 12 de Octubre. Avda. de Córdoba s/n. 28041 Madrid. Spain.