SANCHEZ ZALABARDO, J.M.; BONO ARINO, A.; GRACIA ROMERO, J.    LOPEZ LOPEZ, J.A.. Maternal and perinatal data of hypospadic in a 25 year period. []. , 31, 7, pp.776-780. ISSN 0210-4806.

Objective: To analyze maternal and perinatal risk factors related to the onset and severity of hypospadias. Material and Methods: Data of 614 boys operated on hypospadias in our county during 25 years (1972-1998) has been studied. The patients were divided into 3 groups according the malformation severity: proximal, middle, and distal hypospadias. We use two periods, before and after 1980 to analyze the differences in risk factors along the time. Results: There were 9% of proximal hypospadias, 13,6% middle hypospadias, and 77,5% distal hypospadias. We found statistical significance in several risk factors related to severe hypospadias: low birth weight, intrauterine growth restriction, preterm births, and associated malformations (p<0,001). We did not find statistical significance with maternal age, toxic exposure, associated diseases, and x-ray exposure during pregnancy. After 1980, there were more severe hypospadias and less gestational age. Conclusions: Several events during pregnancy can contribute to the development of hypospadias in the fetus. In our experience, since 1980 there is a rise in the number and severity of hypospadias.

: Hypospadias; Epidemology; Risk Factors.

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