CANALES, A. et al. The effect of consuming meat enriched in walnut paste on platelet aggregation and thrombogenesis varies in volunteers with different apolipoprotein A4 genotype. []. , 25, 5, pp.746-754. ISSN 1699-5198.

Background and aim: Low-fat meat (LM) has been considered adequate under a cardiovascular disease point of view. Meat enriched in walnut paste (WM) consumption produces beneficial antithrombogenic effects but with striking inter-individual variability that may be related to gene polymorphism. Variants in the APOA4 gene (APOA4) polymorphism are known to affect the cardiovascular risk. This study aimed to compare the effects of consumption of WM and LM on platelet aggregation, production of thromboxane A₂ (TXA₂) and prostacyclin I₂ (PGI₂), and the TXA₂/PGI₂ ratio in 22 volunteers with different APOA4 polymorphism. Subjects and Methods: Six volunteers carried the Gln allele (APOA4-2) while 16 were homozygous for the His allele (APOA4-1). Platelet aggregation, TXA₂ (measured as TXB₂), PGI₂ (measured as 6-keto-PGF₁α), and the thrombogenic ratio (TXB₂/6-keto-PGF₁α) were determined at baseline and at weeks 3 and 5 for the WM and LM dietary periods. Results: Platelet aggregation decreased significantly (P<0.05) more in APOA4-1 than in APOA4-2 volunteers at 3-wk WM period, while TXB₂ levels dropped more in APOA4-2 than in APOA4-1 volunteers at 5-wk WM period. TXB₂ levels and the TXB₂/6-keto-PGF₁α ratio decreased significantly more (P<0.05) after 5 wk treatment in APOA4-2 than in APOA4-1 carriers on the WM diet than on the LM counterpart. However, 6-keto-PGF₁α levels increased more (P<0.05) in APOA4-1 than in APOA4-2 volunteers after the 5-wk WM period than after the 5-wk LM diet. Conclusions: Present results suggest that consumption of WM with respect to LM decrease the thrombogenic risk more in Gln carriers than in His/His.

: APOA4 polymorphism; Meat enriched in walnut paste; Low-fat meat; Platelet aggregation; Prostacyclin; Thromboxane; Thrombogenic ratio; Functional food.

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