APARICIO, V. A. et al. Effects of the dietary amount and source of protein, resistance training and anabolic-androgenic steroids on body weight and lipid profile of rats. []. , 28, 1, pp.127-136. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2013.28.1.6055.

Introduction: Dietary protein amount and source, hypertrophy resistance training (RT) and anabolic-androgenic steroids (AAS) may affect body weight and plasma and hepatic lipid profile. Material and methods: 157 adult male Wistar rats were randomly distributed in 16 experimental groups resulting in: normal-protein (NP) or high-protein (HP) diets, whey or soy-protein diets, with or without RT and with or without AAS, for 3 months. Results and discussion: Final body weight was lower in the RT and AAS groups compared to sedentary and non-AAS groups, respectively (all, p<0.001). Plasma total cholesterol (TC) was lower for the HP compared to the NP diets, for the whey compared to the soy-protein diets and for the AAS compared to the non-AAS groups (all, p<0.001). Plasma HDL-cholesterol was higher in the RT groups (p<0.05) but lower for the AAS groups (p<0.001), the HP and the soy-protein diets (p<0.05). Plasma triglycerides (TAG) were lower for the HP diet (p<0.001), for the RT (p=0.002) and the non-AAS groups (p=0.001). Liver TC was lower for the NP (p<0.01), for the soy-protein (p<0.05) and for the AAS groups (p<0.001). Liver TAG were lower for the whey-protein diet (p<0.001), RT and non-AAS groups (both, p<0.05). Some interactions were found, such as the greater effect of AAS on reducing body weight of rats that performed RT or ingested a HP diet (all, p<0.05). HDL-cholesterol was higher when RT was combined with HP diets (p=0.010) or non-AAS and when HP diets were combined with non-AAS (both, p<0.001). Groups that combined RT with non-AAS administration obtained the lowest hepatic TAG (p<0.05). Conclusion: Among all the interventions tested, AAS was the factor that most negatively affected plasma and hepatic lipid profile, whereas HP diets and RT could benefit lipid profile, especially when combined.

: High-protein diet; Anabolic-androgenic steroids; Soy protein; Whey protein; Resistance training; Plasma lipid profile; Hepatic lipid profile; Rats.

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