ARNAIZ, Pilar et al. Subclinical atheroesclerosis and metabolic sindrome in children. []. , 28, 5, pp.1587-1593. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2013.28.5.6767.

Introduction: Metabolic syndrome (MS) in children has been associated to subclinical atherosclerosis as estimated by carotid intima-media thickness (CIMT). Objectives: We aim to ascertain the influence of MS, insulin resistance (IR) and nutritional status on CIMT. Percentiles with an increased risk of CIMT were also explored. Methods: A cross-sectional study of 447 children attending public schools in Santiago, Chile, was performed during years 2009-2011. This sample was selected considering the presence of one or more MS component and IR. Anthropometry and BP were assessed. A blood sample for determination of glycemia, insulinemia and lipids was taken. CIMT was assessed using high resolution ultrasonography with automated software. Pearson correlation, Student's t-test, Chi-squared test, and stepwise logistic regression were computed. Results: Mean age was 11.5 ± 1.0 years old (range 1014); 59% girls; 93% pubertal; 72% excess weight; 24% MS; and 15% IR. Mean values of MS components in children with CIMT ≥ percentile 75 versus < percentile 75 had differences for systolic BP or diastolic BP ≥ percentile 90 (BP ≥ percentile 90) and high density lipoproteins cholesterol ≤ 40 mg/dL (CHDL ≤ 40 mg/dL). The logistic regression for CIMT ≥ percentile 75 only selected BP ≥ percentile 90 and CHDL ≤ 40 mg/dL. The logistic regression for CIMT ≥ percentile 90 did not select independent variables. Conclusions: In this group of children BP ≥ percentile 90 and CHDL ≤ 40 mg/dL values were associated to CIMT ≥ percentile 75. Influences of IR and nutritional status on CIMT were not found.

: Metabolic syndrome X; Insulin resistance; Carotid intima-media thickness; Pediatrics.

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