CABRERA-VIQUE, Carmen; NAVARRO-ALARCON, Miguel; RODRIGUEZ MARTINEZ, Carlos    FONOLLA-JOYA, Juristo. Hypotensive effect of an extract of bioactive compounds of olive leaves: preliminary clinical study. []. , 32, 1, pp.242-249. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2015.32.1.8644.

Objective: to evaluate the possible hypotensive effect in pre-hypertensive and hypertensive subjects of an olive leaf extract (OLE) standardized to 15% (w/w) in oleoeuropein, and with a 10% (w/w) mean content of triterpenic acids and 1% (w/w) in hydroxytirosol. Moreover, the possible effects on the blood antioxidant status and lipid profile have been also evaluated. Material and method: this interventional study has been performed in human volunteers, to whom 1 600 mg OLE/days, was administered. The analyzed parameters at the beginning and end of the study were diastolic and systolic pressure, delay in the LDL-cholesterol oxidation "lag time" and blood levels of nitric oxide (NO), malonic dialdehyde (MDA), antioxidant capacity (AOC) lipid profile, glucose, transaminases and creatinine. Results: a decrease in the diastolic and systolic pressure, and an increase in the NO values all statistically significant (CHO) for all volunteers, was found. In volunteers with higher systolic pressure their levels were also significantly diminished after the intervention trial (P = 0,002). The LDL lag time increased significantly (P = 0,047). Additionally, in all volunteers CHO levels were significantly decreased, and those of LDL cholesterol, triglycerides (TG) and the CHO/HDL cholesterol ratio were diminished with a tendency to the significance (P = 0,076; P = 0,059; P = 0,056; respectively). Conclusion: this preliminary study reports by the first time the positive influence of the OLE assayed in the regulation of the hypertension, LDL lag time and blood lipid profile. Therefore, further studies are of great interest.

: Extract of olive leaves; Oleoeuropein; Triterpenic acids; Hydroxytirosol; Hypotensive effect.

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