AHMAD, Mousa Numan    TAKRURI, Hamid Rabah. The effect of dietary wheat bran on sucrose-induced changes of serum glucose and lipids in rats. []. , 32, 4, pp.1636-1644. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2015.32.4.9457.

Introduction: wheat bran has been known for many health benefits, but its glucose- and lipid-lowering activity still remains unresolved. Objective: to investigate effects of varying amounts of wheat bran and feeding period on serum glucose and lipids in sucrose-fed rats. Methods: eighty male Sprague-Dawley rats were assigned into 4 sucrose-based diets containing either 0, 5, 10 or 20% wheat bran (WB) and given ad libitum to rats for 4, 8, 12 or 16 weeks. Serum glucose, total cholesterol (TC), low- and high-density lipoprotein cholesterol (LDL-C and HDL-C), triglycerides (TG), phospholipids (PL) and total lipids (TL) were quantified at end of each feeding period and other biological parameters were assessed. Results: in all feeding periods, food intake showed ascending linear trend (p < 0.05), whereas body weight did not respond to WB. Compared to 0%, 10 or 20% WB induced decrease (p < 0.05) in TC (16 weeks) and HDL-C (12 or 16 weeks), whereas 5, 10 or 20% WB induced similar decrease in PL (4 or 12 weeks), TL (all periods) and glucose (4 or 8 weeks). This glucose- and lipid- lowering effect was substantiated by descending linear responses (p < 0.05) to WB. PL and TL descending responses to WB were seen in all feeding periods. TG exhibited no change with WB, but linearly responded (4 or 8 weeks). Differences in glucose or lipid variables of rats fed WB diets for all feeding periods were less evident. Conclusions: results suggest that wheat bran reduces serum glucose and lipids mainly phospholipids in sucrose fed rats in an interaction that is likely to have clinical implications in cardiometabolic conditions.

: Wheat bran; Phospholipids; Total lipids; Serum glucose; Cardiometabolic risks; Sucrose.

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