Nutrición Hospitalaria
ISSN 1699-5198 ISSN 0212-1611
ARRIETA LOITEGUI, María et al. Black precipitate in parenteral nutrition. []. , 36, 4, pp.753-757. 17--2020. ISSN 1699-5198. https://dx.doi.org/10.20960/nh.02311.
Introduction:
a black precipitate was observed in the filter during the infusion of a parenteral nutrition without lipids. There are similar findings published in which copper and sulphur (from cysteine) were found in the composition of the precipitate.
Objective:
to determine if copper and cysteine are involved in the formation of the precipitate.
Methods:
samples of the parenteral nutrition solution were taken before and after its passage through the filter. Amino acids concentrations were analysed in both samples by ion exchange chromatography and post-column derivatization with ninhydrin in a Biochrom 30 device. Copper concentrations were measured by atomic absorption spectrometry in a PerkinElmer AAnalyst(tm) 200 device.
Results:
a decrease in cysteine concentration of 29.3% was found. The concentration of copper decreased by 75.9%.
Conclusions:
the decrease in the concentrations of cysteine and copper in the filtered solution suggest that both are involved in the formation of the black precipitate observed in the filter.
: Parenteral nutrition; Chemical precipitation; Filtration; Copper; Cysteine; Amino acids.