Nutrición Hospitalaria
ISSN 1699-5198 ISSN 0212-1611
ZAIBIBULI, Kaibinuer et al. Dietary inflammatory index and its association with leptin and adiponectin in Uygur overweight/obese adults. []. , 40, 4, pp.739-745. 20--2023. ISSN 1699-5198. https://dx.doi.org/10.20960/nh.04281.
Introduction:
chronic inflammation contributes to a wide range of metabolic disorders through the influence of diet. The dietary inflammatory index (DII) was developed to measure the inflammation potential of diet.
Objectives:
Uygur adults have a high prevalence of obesity, but the causes of this condition remain unclear. In this study we investigated the association between DII and adipocytokines among overweight and obese Uygur adults.
Methods:
a total of 283 obese and overweight Uygur adults were included. Sociodemographic characteristics, anthropometric measurements, dietary surveys and biochemical indicators were collected by standardized protocols. The DII score was calculated using a valid and reliable 93-item food frequency questionnaire (FFQ). Linear regression was used to estimate the relationship between DII and adipocytokines.
Results:
the DII score was 1.35 ± 1.08, ranging from -2.14 to +3.11. There was a significant inverse correlation between DII and high-density lipoprotein cholesterol (HDL-C) in the unadjusted model (β = -0.12, p = 0.02), and this remained after adjustment for age, gender, body mass index (BMI). DII was negatively associated with adiponectin (ADPN) (β = -203.15, p = 0.04) and positively associated with leptin (LEP) concentration (β = 1.64, p = 0.002) after adjustment for age, gender and BMI.
Conclusion:
a pro-inflammatory diet, as indicated by a higher DII score, is associated with adipose tissue inflammation in Uygur adults and supports the hypothesis that diet may play a role in the development of obesity through inflammatory modulation mechanisms. A healthy anti-inflammatory diet is feasible for obesity intervention in the future.
: Dietary inflammatory index; Obesity; Leptin; Adiponectin.