CANDEL GONZALEZ, F. J.; MATESANZ DAVID, M.    CANDEL MONSERRATE, I.. Primary adrenal insufficiency: Addison´s disease. []. , 18, 9, pp.48-54. ISSN 0212-7199.

Addison's disease is due to an insufficiency of corticosuprarrenal hormons to mantain the peripheral needs and its clinical sign is a constitutional syndrome with cutaneous hyperpigmentation and low blood preassure. The ethiology has drastically variated in the last century; being the origin almost exclusively tuberculous at the begining of 1900 and mainly autoimmune actually. Nowadays it is difficult to understand Addison's disease out of the context of autoimmune polyglandular syndromes in view of the frequent association to other endocrinopathys. The present article pretends to realize a vision of the global disease related to these multiple endocrine deficits.

: Adrenal insufficiency; Addison disease; Etiology; Diagnosis; Therapy; Polyglandular tuoinmune syndrome.

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