KHOSRAVI SHAHI, P.; CASTILLO RUEDA, A. del    PEREZ MANGA, G.. Neoplastic angiogenesis. []. , 25, 7, pp.366-369. ISSN 0212-7199.

Neoplastic angiogenesis is an essential process in the progressive growth of neoplasms and the production of metastasis. Angiogenesis consists of a series of linked and sequential steps that ultimately leads to the development of a neovascular blood supply to the tumor mass. VEGF has got an essential role in neoplastic angiogenesis, therefore it is an important target in the treatment of neoplasms. Bevacizumab, a humanized monoclonal antibody, inhibits VEGF, and may also improve the delivery of chemotherapy to the tumor mass. Multi-kinase ihibitors (sorafenib and sunitinib) are orally administered small-molecules, that inhibit different receptors (essentials in the neoplastic angiogenesis), such as the VEGFR or PDGFR. These agents are useful in the treatment of advanced renal-cell carcinoma, and are under investigation in several tumors.

: Cancer; VEGF; Bevacizumab; Sorafenib; Sunitinib.

        · |     · |     · ( pdf )