ROJAS DE MORALES, Thais et al. pH and salivary sodium bicarbonate during the administration protocol for methotrexate in children with leukemia. []. , 12, 6, pp.435-439. ISSN 1698-6946.

^len^aObjective: To analyze the behavior of pH and sodium bicarbonate (NAHCO3) in the saliva of patients with leukemia during the administration protocol for Methotrexate (Mtx). Materials and Methods: A controlled clinical essay was carried out on 23 patients between 4 and 18 years of age with high-risk Acute Lymphoblastic Leukemia. Sampling was carried out at T_o: basal condition; T₁: 12 hours after intravenous administration of sodium bicarbonate, before administering Mtx and T₂: 3 hours after administering Mtx, the time of maximum concentration. Chiron-Diagnostic 378^® equipment was used to determine pH and sodium bicarbonate. The data was interpreted using Analysis of Variance at the 5% significance level. Results: The highest values of sodium bicarbonate were observed at T₂, with salivary pH levels remaining within neutrality ranges, diminishing slightly in T₁. Conclusion. In this study, the dose of sodium bicarbonate considered in the administration protocol of 3 g /m² Mtx, kept sodium bicarbonate levels in saliva at normal levels and pH neutral.

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