VARELA-REY, I et al. Galenic aspects of submucosal injection solutions for use in endoscopic polypectomy. []. , 30, 2, pp.131-139.   15--2021. ISSN 1699-714X.  https://dx.doi.org/10.4321/s1699-714x2020000200013.

Endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) are the main techniques used in the removal of intestinal polyps. In both techniques a submucosal solution is injected to create a hub under the lesion that separates the mucosa from the muscular layer itself. This allows a better delimitation of the lesion and facilitates its resection.

In clinical practice, many solutions have been tested for this use, being used in most cases out off-label and without galenic, physicochemical or microbiological control, despite being parenteral administration solutions.

The objective of this study is to carry out a review of the main solutions used, as well as their limitations and the main advances made in this area.

: Submucosa; injection solution; polypectomy; endoscopic.

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