Revista de la OFIL
ISSN 1699-714X ISSN 1131-9429
SAEZ-TORRES DE VICENTE, M; LOPEZ-SANTAMARIA DONOSO, J AUMENTE RUBIO, MD. Vancomycin dosage in patients undergoing intermittent dialysis. Preparation of an initial dosage protocol. []. , 31, 1, pp.28-31. 07--2021. ISSN 1699-714X. https://dx.doi.org/10.4321/s1699-714x2021000100007.
Objective:
To review the initial dosage of vancomycin in patients on intermittent hemodialysis, to establish a dosing protocol that allows reaching an optimal pre-dialysis concentration (15-20 µg/ml) after loading dose and first maintenance dose.
Method:
Observational, retrospective, unicentric study in which all hemodialysis (HD) patients who received vancomycin, during the last hour of the session, between September 2010 and January 2018, were included.
Results:
87 patients were included, considering the value optimal Cmin=15-20 µg/ml, only 12.6% of the patients after the loading dose and 18.4% after the maintenance dose reached the reference value.
Conclusions:
The initial empirical regimen of vancomycin was insufficient in most patients to reach optimal concentrations from the beginning of treatment, so a new dosing protocol adapted to the patient's weight is proposed.
: Vancomycin; hemodialysis; optimal concentration; dosage; protocol.