Abstract

SAN MIGUEL FRAILE, P. et al. Comparative analysis of p53, Ki-67, bcl-2 and CK20 expression in superficial transitional cell carcinoma of urinary bladder: correlation with recurrence, histological grade and clinical stage. Actas Urol Esp [online]. 2003, vol.27, n.8, pp.587-593. ISSN 0210-4806.

OBJETIVE: We examined the presence of p53, Ki-67, bcl-2 and CK20, as detected by immunohistochemistry, and correlated with the classic variables (grade, stage and recurrence). MATERIAL AND METHOD: The authors evaluated 57 superficial transitional cell carcinomas. Biopsy specimens examined included non recurrent transitional cell carcinomas (n=36) and recurrent transitional cell carcinomas (n=21). Association of bcl-2, p53, Ki-67 y CK20 index immunoreactivity with tumor grade, clinical stage and tumor recurrence was examined. RESULTS: Ki-67 and p53 expression were related to the degree of differentiation and recurrence of the disease. bcl-2 and CK20 were not correlated with grade, stage and recurrence of the disease. CONCLUSIONS: Positivity for Ki-67 and p53 increase with grade of the disease. P53 and Ki-67 are predictors of tumor recurrence for patients with superficial transitional cell carcinoma.

Keywords : Transitional cell carcinoma; Bladder; p53 protein; Ki-67; bcl-2; CK20.

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