Abstract

CORTES-GONZALEZ, J.R.  and  GLINA, S.. Conservative treatment of Peyronie's disease: Colchicine vs. colchicine plus vitamin E. Actas Urol Esp [online]. 2010, vol.34, n.5, pp.444-449. ISSN 0210-4806.

Objective: To retrospectively review the response of patients with Peyronie’s disease (PD) treated with colchicine as monotherapy and colchicine plus Vitamin E. Material and methods: We evaluated 100 men with PD. A dose of 1.5mg/day oral Colchicine as monotherapy (CCM) was given to 59 patients and 1.5/800mg/day oral Colchicine/Vitamin E (CCVE) to 41. Response was categorized as follows: Good response, when at least 2 of the following conditions were achieved: Decrease/stabilization of curvature and/or plaque and/or pain relief. Partial response if one of the former conditions were observed. No response and worsening. No statistical differences between groups were found. Results: Good response was observed in 39% vs 41% in the CCM and CCVE groups respectively. When looking at each variable, we observed improvement on the plaque’s size in 36 vs 29%, pain relief in 46 vs 57% and curvature 32 vs 33% in the CCM and CCVE respectively. None of these differences were statistically significant. Conclusion: Oral conservative treatment with CCVE failed to show statistically significant differences in efficacy in pain relief, penile curvature or plaque size against CCM in this study. However, there is slight evidence of a positive prognostic effect on the conservative treatment when history of previous unsuccessful PD treatment was recorded, this was statistically significant in the CCVE group, supporting the theory of a combined treatment. A randomized double blind placebo controlled study with a sample size calculation should be performed to confirm our results.

Keywords : Peyronie's disease; Colchicine; Vitamin E; Drug therapy; Penile curvature.

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