Abstract

LOPEZ FONTANA, C.M. et al. Relation between selenium plasma levels and different prostatic pathologies. Actas Urol Esp [online]. 2010, vol.34, n.7, pp.625-629. ISSN 0210-4806.

Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). Objective: To determine and compare selenium plasma levels in patients with different prostatic pathologies. Material and methods: It is a transversal, descriptive and comparative study. A sample of 64 men between 50 and 80 years old were selected for the study between 2007 and 2009. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy (12-14 chips). Prostate cancer was subclassified according to Gleason Score. Selenium was determined indirectly by serum Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical analysis was performed using ANOVA I (p<0.05). Results: Glutathione Peroxidase level was 33.75±2.36mg/ml in control patients. A decrease of 31.6% was observed in patients with BPH (23.08±1.57mg/ml) and of (63.6%) in subjects with prostate cancer (12.28±1.03mg/ml) (p<0,0001). There was no correlation with the Gleason Score. Conclusion: Serum Seleniun is lower in patients with prostatic pathologies being even more important in cancer patients regardless the Gleason Score.

Keywords : Selenium; Prostate cancer; Benign prostatic hyperplasia; Chronic prostatitis.

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