Abstract

ARRATIA-MAQUEO, J.A.; GARZA-CORTES, R.; GOMEZ-GUERRA, L.S.  and  CORTES-GONZALEZ, J.R.. Effect of one month treatment with dutasteride on transurethral resection of the prostate. Actas Urol Esp [online]. 2010, vol.34, n.10, pp.866-869. ISSN 0210-4806.

Objective: Evaluate the effect of dutasteride in perioperative bleeding during Transurethral Resection of Prostate (TURP). Materials and Methods: Forty consecutive patients with criteria for TURP were included. Finasteride/dutasteride use, renal impairment, prostate <30cc, age <50 were excluded. Patients were divided in 2 groups. Group 1: 24 consecutive patients treated with dutasteride 0.5mg/day/30-days prior TURP. Group 2: 16 without treatment. Prostatic volume, difference in hemoglobin pre/post TURP, duration and amount of resected tissue were recorded. Surgeon was blinded. Statistical analysis: Multiple linear regression, Mann-Whitney and student t-tests were used. Results: In group 1, 33%(8) improved their lower urinary tract symptoms and skipped TURP. Mean Hemoglobin loss difference between groups was 0.11gr/dl (CI 95% -0.55; 0.77, p=0.88). There was no statistical difference among variables. No positive or negative predictive values in the linear regression model. Conclusion: Dutasteride did not significantly impact the studied variables in these non randomized and small sample size settings.

Keywords : Benign Prostatic Hyperplasia; Hematuria; Finasteride; Transurethral resection of the prostate; Dutasteride.

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