Abstract

MINAMBRES, E. et al. Comparative study of two preservation solutions in the initial function of transplant of both lungs in humans. Med. Intensiva [online]. 2007, vol.31, n.1, pp.1-5. ISSN 0210-5691.

Objective. Compare the influence of two preservation liquids, Euro-Collins (EC) and Perfadex (P) in the pulmonary graft function in the initial phase of lung transplant in humans. Design. Retrospective study. Scope. Lung transplant unit of the ICU of a university hospital. Patients. A total of 79 patients were subjected to a transplant of both lungs. The pulmonary grafts were preserved with EC in 23 cases and with P in 56 cases. Variables of interest. Pulmonary function was assessed on admission in the intensive care unit (ICU) with the PaO₂/FiO₂ ratio. Mortality, graft dysfunction stay in ICU and time of mechanical ventilation were also assessed at 30 days. Results. The PaO₂/FiO₂ ratio was significantly greater in the P group than in the EC both on admission (p < 0.006) and at 12 hours (p = 0.032) in the ICU. Graft dysfunction incidence was less in group P than in EC (p < 0.045). There were no differences in regards to mortality at 30 days, stay in ICU and time of mechanical ventilation between both groups. Conclusion. Preservation of the pulmonary graft with P as preservation liquid compared with EC is associated with better graft function in the initial phases of transplant of both lungs and with a decrease in the incidence of graft dysfunction

Keywords : lung transplant; preservation solutions; pulmonary function; prognosis.