Abstract

GONZALEZ CASTRO, A; SUBERVIOLA CANAS, B; MINAMBRES, E  and  ORTIZ MELON, F. Recombinant factor VIIa (rFVIIa): Description of use in a cohort of critical patients and prognostic markers. Med. Intensiva [online]. 2007, vol.31, n.5, pp.215-219. ISSN 0210-5691.

Objective. Describe and identify the factors associated with the survival of the patients who received treatment with rFVIIa in an Intensive Care Unit (ICU) Design. Longitudinal, ambispective, observational, descriptive study in a series of clinical cases performed from July 20, 2004 to July 20, 2006. Scope. The study population included 16 hospitalized patients in the Intensive Medicine Department (ICU) of the Hospital Marqués de Valdecilla (Santander). Patients. Inclusion criteria were: Patients who required rFVIIa at some time of their stay in the ICU. Results. Hemodynamic improvement of the patients treated with rFVIIa in an ICU, within the first 3 hours of the infusion (evaluated by an increase of SBP 20 mmHg and/or increase of DBP 8 mmHg) was associated to greater survival. Conclusions. The present series of cases, with the disadvantage of its heterogeneity and the limited number of patients, stresses the role of hemodynamic improvement as a differentiating factor between those patients who survive and those who do not.

Keywords : recombinant activated factor VII; prognostic markers.