Abstract

SELLER-PEREZ, Gemma et al. Liver transplantation: influence of donor-related factors. Med. Intensiva [online]. 2008, vol.32, n.8, pp.378-384. ISSN 0210-5691.

Objective. To detect donor characteristics related to graft function after orthotopic liver transplantation (OLT). Design. Retrospective cohort study. Context. Polyvalent intensive care unit. Patients. 145 liver transplant recipients and their respective donors. Interventions. None. Main variables of interest. In donors: age, hypernatremia, and infection. In recipients: reperfusion syndrome, coagulopathy, infection, ARDS, shock, kidney failure, primary graft dysfunction, and mortality. Results. 71.7% of recipients were male. Mean recipient age was 54.5 ± 9.9 years; 66.2% of patients were classified as Child B and and 19.3% as Child C. The mean model for end-stage liver disease (MELD) score was 14.6 ± 4.8 and the mean APACHE II score was 17.3 ± 4.9. A total of 64.1% of the donors were male. Mean donor age was 42.3 ± 16.3 years, and mean APACHE II score was 22.3 ± 5.8. Donor age > 65 years was associated to higher recipient aspartate aminotransferase (AST) levels but not to increased complications or mortality. No other donor factors (including age, sex, serum sodium, severity level, transfusions, hemodynamic alterations, renal dysfunction, or infection) were associated to evolution or prognosis. Infection was diagnosed in 18 recipients (12.4%) in the postoperative period; the incidence of infection in recipients that received an organ from infected donors was not different from those that received an organ from an uninfected donor (14.6% versus 11.5%; p > 0.05). Conclusions. We detected no donor characteristics related to graft function or the appearance of complications in recipients during the immediate postoperative period. Donor age > 65 years and documented but appropriately treated bacteremia posed no risk for the viability of the liver after transplantation.

Keywords : Liver transplantation; Donor selection; Mortality.

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