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Medicina Intensiva
Print version ISSN 0210-5691
Abstract
GORDO-VIDAL, F.; CALVO-HERRANZ, E.; ABELLA-ALVAREZ, A. and SALINAS-GABINA, I.. Hyperoxia induced pulmonary toxicity. Med. Intensiva [online]. 2010, vol.34, n.2, pp.134-138. ISSN 0210-5691.
Mechanical ventilation may cause and aggravate lung damage and contribute to the appearance of multiorgan failure. One of the mechanisms that has been described is alveolar hyperoxia. In experimental models, it has lead to the production of free oxygen radicals that exceed the cell defense capacity, giving rise to inflammation, cell damage and gene overexpression with necrosis and apoptosis phenomenon. However, these findings in humans are not as conclusive, although a functional alteration due to the exposure to high FiO2, and greater lung de-recruitment in patients with lung injury has been clearly demonstrated. Moreover, both the FiO2 used as well as the PaO2 achieved in the first 24h of admission are associated with mortality. Clinical trials are needed that assess the threshold of the safe oxygen level for FiO2 and oxygen saturation.
Keywords : Hyperoxia; Lung injury; Artificial respiration; Adverse effects; Complications.