Abstract

OLIVERA-GONZALEZ, S. et al. Metformin-associated hepatotoxicity. Med. Intensiva [online]. 2010, vol.34, n.7, pp.483-487. ISSN 0210-5691.

Metformin is an oral biguanide widely used in the management of patients with type 2 diabetes. It produces non-specific gastrointestinal symptoms in 10-30% of the patients. Lactic acidosis is the most serious side effect, so it must not be administered to patients with renal, liver, or heart insufficiency. Only a few cases of hepatotoxicity due to this drug have been documented. We report the case of a patient with type 2 diabetes mellitus and recent use of metformin who developed serious liver injury, followed by a favorable evolution.

Keywords : Metformin; Hepatotoxicity; Idiosyncratic.

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