Abstract

CARDINAL-FERNANDEZ, P.; NIN, N.  and  LORENTE, J.A.. Acute lung injury and acute respiratory distress syndrome: a genomic perspective. Med. Intensiva [online]. 2011, vol.35, n.6, pp.351-372. ISSN 0210-5691.

Genomics have allowed important advances in the knowledge of the etiology and pathogenesis of complex disease entities such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Genomic medicine aims to personalize and optimize diagnosis, prognosis and treatment by determining the influence of genetic polymorphisms in specific diseases. The scientific community must cope with the important challenge of securing rapid transfer of knowledge to clinical practice, in order to prevent patients from becoming exposed to unnecessary risks. In the present article we describe the main concepts of genomic medicine pertaining to ALI/ARDS, and its currently recognized clinical applications.

Keywords : Polymorphism; ALI; ARDS; Susceptibility; Genomic; Critical care.

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