Abstract

MARTINEZ-PASTOR, Carlos J.  and  REAL ROMAN, Vicente. Proposal of a model of schizophrenic delusions' response to antipsychotics. Rev. Asoc. Esp. Neuropsiq. [online]. 2016, vol.36, n.129, pp.15-28. ISSN 2340-2733.

Despite recent advances in psychopharmacology, some obvious questions regarding the day-to-day practice do not use to draw attention of researchers. Our model tries to explain the variable response of schizophrenic delusions to antipsychotic drugs. It is a model composed of two poles. In one of them the principle of conditioned avoidance response applies, which refers to the ataraxic or neuroleptic effect of antipsychotic drugs. At the other end of the model Husserl's phenomenology is applied to psychopathology in order to organize diverse and distinctive phenomena of schizophrenia. Results of this research are then related to the dopaminergic aberrant salience occurring in the schizophrenic outbreak. Finally, constraints of this work are pointed out, which are the same for the very foundations of psychiatry, a medical specialty compelled to move between fields of knowledge mutually irreducible such as neuroscience and human experience.

Keywords : dopamine; antipsychotics; schizophrenia; conditioned avoidance; self-disturbances; psychopathology.

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