Abstract

ROSA GARCIA, E. de la  and  MONDRAGON PADILLA, A.. Mofetil mycophenolate and azathioprine effect on cyclosporin a - associated gingival overgrowth in renal transplant patients. Nefrología (Madr.) [online]. 2009, vol.29, n.5, pp.474-478. ISSN 1989-2284.

Aim: To assess gingival overgrowth prevalence and severity in a group of kidney transplant (KT) patients, and analyze the effect of immunosuppressor drugs Cyclosporin A (CyA), Tacrolimus (Tac), Sirolimus (Siro), Azathioprine (Aza) and Mofetil Mycophenolate on this complication. Methods: Gingival overgrowth presence and severity was classified, and the impact of immunosuppressor drugs, age, oral hygiene, verapamil and nifedipine on this condition was analyzed by multiple logistic regression. Results: 172 KT pts. were examined; 137 used CyA, 25 Tac, 6 Sirolimus, 107 Aza and 56 MMF. Gingival overgrowth prevalence was 59.1% on CyA, 12.0% on Tac, and 16.7% on Sirolimus. CyA odds ratio (OR) 15.2, age < 45 OR 5.6, and poor oral hygiene OR 3.2 increased, and Aza OR 0.05 and MMF OR 0.03 decreased GO prevalence. Conclusions: Aza and MMF effect was a significant protection against GO in this group of KT patients.

Keywords : Gingival overgrowth; Azathioprine; Mofetil mycophenolate; Cyclosporin A; Renal transplant.

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