Abstract

RAMON, Peces Serrano; AZORIN, S.; PECES, C.  and  SELGAS, R.. Extended hemoperfusion in the treatment of acute carbamazepine intoxication. Nefrología (Madr.) [online]. 2010, vol.30, n.1, pp.127-130. ISSN 1989-2284.

Carbamazepine is used in the treatment of epilepsy, and also prescribed in neuralgic pain syndromes, and certain affective disorders. Carbamazepine intoxication with suicide attempt is a relatively common clinical problem that can result in coma, respiratory depression, arrhythmia, hemodynamic instability and death. The drug's relatively high molecular weight, elevated volume of distribution and intense protein-binding render it difficult to extracorporeal removal, but published experience with hemoperfusion or hemodialysis present variable results. We describe a case report involving carbamazepine intoxication who was successfully treated with charcoal hemoperfusion. With this treatment the half-life of carbamazepine was reduced with rapid lowering of carbamazepine levels and clinical improvement. Based on our experience in this patient and a review of previously reported cases, extended charcoal hemoperfusion should be considered for serious carbamazepine intoxication because free as well as bound drug fractions are eliminated via this technique.

Keywords : Hemodialysis; Hemoperfusion; Carbamazepine intoxication; Suicide attempt.

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