Abstract

RAMIREZ A., M.ª M. et al. Effect of a high glucose load on serum concentrations of C-reactive protein and α1-antitrypsin in obese women. Nutr. Hosp. [online]. 2008, vol.23, n.4, pp.340-347. ISSN 1699-5198.

Obesity is associated with increased inflammation. C-reactive protein (CRP) is a proinflammatory molecule, and α1-antitrypsin is an inflammation-sensitive plasma protein. Proinflammatory process may be influenced by postprandial hyperglycemia. Objective: The aim of the present study was to evaluate the role of high-glucose load on postprandial circulating levels of PCR and α1-antitrypsin in obese women with normal glucose tolerance. Design: A total of 15 obese women (age = 34.4 ± 4.3 years, BMI = 35.5 ± 5.3 kg/m²) and 15 lean controls women (age = 33.9 ± 2.9 years, BMI = 21.8 ± 1.9 kg/m²) were recruited for this study. After and overnight fast subjects underwent a 2 h-75 g oral glucose tolerance test. Preprandial and postprandial CRP and α1-antitrypsin were measured. Anthropometry and blood biochemical parameters were measured in both groups. Results: The obese women had fasting serum PCR levels higher (P = < 0.001) than those of control women. There weren't differences in fasting serum α1-antitrypsin levels in obese group in comparison to lean control group (P = 0.26). Serum PCR and α1-antitrypsin did not change postprandially (P = > 0.05 difference to fasting levels). Serum CRP levels was positively related to body mass index (BMI) in obese group. Serum α1-antitrypsin was not related to BMI in both groups. Conclusion: A high glucose load is not associated with serum PCR and α1-antitrypsin levels increase. Serum α1-antitripsin levels are not increased in obese women. Serum PCR levels are increased in obese women, and are positively related to BMI.

Keywords : C-reactive protein; α1-antitrypsin; Obesity; Hyperglicemia.

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