Abstract

RAMIREZ ALVARADO, M.ª M.; SANCHEZ ROITZ, C.; PEREZ DIAZ, A.  and  MILLAN BRITO, E.. Effect of a high saturated fatty acids load on serum concentrations of C-reactive protein, a1-antitrypsin, fibrinogen and a1-acid glycoprotein in obese women. Nutr. Hosp. [online]. 2010, vol.25, n.1, pp.72-79. ISSN 1699-5198.

Obesity is associated with increased inflammation. Creactive protein (CRP) and inflammation-sensitive plasma protein (ISPs) are inflammatory markers. Proinflammatory process may be influenced by high saturated fatty acid intake. Objective: The aim of the present study was to evaluate the role of saturated fatty acids load on postprandial circulating levels of PCR and ISPs (a1-antitrypsin, a1-acid glucoprotein, and fibrinogen) in obese women. Design: A total of 15 obese women (age = 31,7 ± 4,5 years, BMI = 37,9 ± 7,3 kg/m²) and 15 lean controls women (age = 30,6 ± 4,6 years, BMI = 20,6 ± 2,6 kg/m²) were recruited for this study. After and overnight fast subjects ate the fat load consisted of 75 g of fat (100% saturated fatty acid, 0% cholesterol), 5 g of carbohydrates, and 6 g of protein per m2 body surface area. Postprandial serum levels of CRP, a1-antitrypsin, a1-acid glucoprotein, and fibrinogen were measured. Anthropometry and blood biochemical parameters were measured in both groups. Results: The obese women had fasting serum PCR levels higher (p = 0,013) and fibrinogen (p = 0,04) than those of control women. Serum CRP and fibrinogen levels was positively related to body mass index (BMI) in obese group. There weren't differences in fasting serum a1- antitrypsin levels (p = 0,40), and a1-acid glucoprotein (p = 0,28) levels in obese group in comparison to lean control group. Serum CRP, a1-antitrypsin, a1-acid glucoprotein, and fibrinogen did not change postprandially (p = > 0,05 difference to fasting levels). Conclusion: A high-saturated fatty acids load is not associated with serum CRP, a1-antitrypsin, a1-acid glucoprotein, and fibrinogen levels increase. Serum a1-antitripsin and a1-acid glucoprotein levels are not increased in obese women. Serum PCR and fibrinogen levels are increased in obese women, and are positively related to BMI.

Keywords : C-reactive protein; a1-antitrypsin; a1-acid glucoprotein; Fibrinogen; Obesity.

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