Abstract

NOGUEIRA, Carla R. et al. Effects of supplementation of antioxidant vitamins and lipid peroxidation in critically ill patients. Nutr. Hosp. [online]. 2013, vol.28, n.5, pp.1666-1672. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2013.28.5.6590.

Introduction: Critical patients present systemic inflammatory process that can be followed by decrease in plasma concentrations of antioxidant vitamins. Objetive: The aim of this study was to evaluate the effect of the supplementation of antioxidant vitamins in critical patients and their relation with lipid peroxidation. Methods: 23 patients went on a standard diet (G1) and 11 went on a diet with daily supplementation of 10,000 IU of vitamin A, 400 mg of vitamin E and 600 mg of vitamin C (G2). The APACHE II score was made. Serum concentrations of retinol, β-carotene, vitamins C and E, malon-dialdehyde (MDA) and C-reactive protein was measured before (T0) and on the 8^th day after the beginning of the nutritional therapy (T1). The groups had been monitored on T0, T1 and T2, (at discharges or death) on the following parameters: mechanical ventilation; hospitalization days; mortality; infection incidence. Results: Serum concentrations of MDA and vitamin E were significantly lower in G2 after intervention and strong tendency to increase vitamin C. There were not significant differences between the groups regarding the clinical parameters. Conclusions: The doses of vitamin A, C and E that were indicated were effective for the current lipid peroxidation reduction.

Keywords : Vitamin antioxidant; Malondialdehyde; Critical patient; Lipid peroxidation.

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