Abstract

GARCIA RODRIGUEZ, María del Carmen; MATEOS NAVA, Rodrigo Aníbal  and  ALTAMIRANO LOZANO, Mario. In vivo effect of red wine undiluted, diluted (75%) and alcohol-free on the genotoxic damage induced by potential carcinogenic metals: chromium [VI]. Nutr. Hosp. [online]. 2015, vol.32, n.4, pp.1645-1652. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2015.32.4.9520.

Introduction: the carcinogenesis may be initiated and promoted by the oxidative DNA damage. The compounds of chrome (Cr [VI]) cause oxidative stress (EOx) and are recognized as carcinogens in humans. In this sense, it is proposed that drinks with a high antioxidative potential, such as red wine, may have protective or modulatory effects on the oxidative DNA damage. Objective: to study the effects of the administration in vivo of undiluted, diluted (75%) and alcohol-free red wine on the genotoxic damage induced by carcinogenic metals (Cr [VI]), by evaluating the micronucleus (MN) in polychromatic erythrocytes (EPC) in mice (CD-1). Material and method: it was randomly organized the follow groups: (i) control, (ii) undiluted, diluted and alcohol-free red wine (free access), (iii) CrO₃ (20 mg/kg by intraperitoneal route) and (iv) CrO₃-red wine. The evaluations were made in blood samples obtained from the caudal vein, in which it was identified the MN and EPC before, during and after treatments. Results and discussion: the red wine (diluted and alcohol-free) was capable of decreasing the averages of MN induced by CrO₃, demonstrating its modular capacity in vivo in the oxidative DNA damage caused by EOx-induced carcinogens. The administration of only undiluted red wine presented toxic effects. Conclusions: our results raises expectations on the use of substances like the red wine for the protection or modulation of genotoxic damage, encouraging its application in the carcinogenic and mutagenic processes.

Keywords : Red wine; Alcohol; Chrome [VI]; Antigenotoxic; Cancer prevention.

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