Abstract

LIZARRAGA-CANEDO, Jonathan; ROBLES-SARDIN, Alma; SALAZAR, Gabriela  and  ALEMAN-MATEO, Heliodoro. Effect of overweight and obesity on the equilibrium time, but no in the total body water and body composition compartments in women subjects over 60 years of age. Nutr. Hosp. [online]. 2015, vol.32, n.6, pp.2792-2799. ISSN 1699-5198.  https://dx.doi.org/10.3305/nh.2015.32.6.9807.

Introduction: aging and obesity cause changes in water exchange rate, which could affect the equilibrium time of deuterium oxide (²H₂O). Objective: to assess the effect of overweight and obesity on the equilibrium time of the stable isotope deuterium in saliva samples of older adults. Methods: a sample of 18 women over 63 years with a body mass index (BMI) of 20.8 to 40.5 kg/m² were included. A basal saliva sample was took and immediately a dose of 30 g of ²H₂O was administered orally. Saliva samples at 2, 2.5, 3, 3.5 and 4 hours post-dose were taken. Deuterium in saliva samples were analyzed by Fourier Transform Infrared spectroscopy technique. Results: the average in equilibrium time (plateau) in women of normal BMI (18.5-24.9 kg/m²) was 3.6 ± 0.2 hours, which was statistically different to those obtained in the group with overweight (25-29.9 kg/m²) and obese (>30 kg/m²) of 2.9 ± 0.4 hours and 2.8 ± 0.4 hours, respectively (p<0.05). The values of total body water and fat free mass calculated with the values of isotopic enrichment at 3.6 (plateau reached in the group with normal BMI) did not differ statistically from the values calculated to plateau at 2.9 and 2.8 hours in the overweight and obesity group, respectively (p>0.05). Conclusion: obesity had an effect on the equilibrium times; however, did not affect the calculation of total body water and body composition in this older women adult group.

Keywords : Aging; Obesity; Equilibrium time; Deuterium and total body water.

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