Abstract

MARTINEZ-LOZANO ARANAGA, Fátima et al. Comparative study on the efficacy and safety of parenteral nutrition formulated with two different fat emulsions: SMOFlipid^® compared with Clinoleic^®: preliminary study. Nutr. Hosp. [online]. 2016, vol.33, n.3, pp.515-521. ISSN 1699-5198.  https://dx.doi.org/10.20960/nh.252.

Introduction: The fat composition of parenteral nutrition formulae has been put forward as a possible factor in clinical evolution. Objective: To evaluate the differences in efficacy and safety of two (2) fat emulsions for parenteral nutrition. Material and methods: Prospective clinical study of post-surgery patients under PN for more than seven days in a two-year period. Two types of fat emulsions were administered indistinctively. One is enriched with omega 3 fatty acids (SMOFlipid Fresenius Kabi^®), the other one is enriched with omega 9 oleic acid (Clinoleic Baxter^®). Epidemiological and analytical variables, infectious complications and mortality were analysed. Results: A total of 154 patients were studied. Their average age was 64.36 ± 13.73 years; 95 were men (61%). Out of the total number, 78 (51%) were given SMOFlipid^® and 76 (49%) Clinoleic^®. Average stay was 16.91 ± 4.23 days, parenteral nutrition was administered for 9.68 ± 3.25 days, mortality was 11%. 58 (37%) infections were diagnosed. When measured on the first (1st) and seventh (7th) days, there were no significant differences in regard to the lipid, hepatic or nutritional parameters, nor in their evolution (average stay, infectious complications, or mortality) between the two groups of patients. Conclusion: Patients on parenteral nutrition show similar evolutionary characteristic, independently of the fat emulsion administered. Current bibliography would suggest that a benefit could be gained from reducing the administration of omega 9 fatty acids, but no significant differences were found when comparing the two formulae.

Keywords : Parenteral nutrition; Fat emulsions; Complications; Infection; Mortality.

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