Abstract

BUENO VARGAS, Pilar; MANZANO MARTIN, Manuel; LOPEZ ALIAGA, Inmaculada  and  LOPEZ PEDROSA, José M.ª. Influence of supplementation with oligofructose-enriched inulin on bone mineral content and density after delivery and lactation in rats. Nutr. Hosp. [online]. 2016, vol.33, n.5, pp.1074-1081. ISSN 1699-5198.  https://dx.doi.org/10.20960/nh.569.

Introduction: Pregnancy and lactation are related with temporary decreases in maternal bone mineral density (BMD). Calcium supplementation could be beneficial to prevent bone loss of maternal skeleton. Other nutrients, such as prebiotics have showed to produce an increase of the mineral absorption and therefore affecting bone mineralization. Objective: To study the effect of maternal diet supplementation with prebiotic oligofructose-enriched inulin during gestation and lactation on the maternal bone mineral content (BMC) and BMD at the end of lactation. Methods: Pregnant rats were fed with standard diet (CC group), calcium fortified diet (Ca group) or with prebiotic oligofructose-enriched inulin supplemented diet until the end of the lactation period. At weaning, bone mineral content (BMC) and BMD were determined by dual-energy X-ray absorptiometry and the pH of the cecal content was also determined. Results: In absolute terms, the highest BMD and BMC were found in the Pre group as compared with the other two groups being significant in the tibia when compared Pre group and CC group with Ca group. The pH of the cecal content in the Pre group was also significantly lower as compared with the other two groups. Conclusion: Prebiotic oligofructose-enriched inulin supplementation, in calcium no-deficient conditions, during gestation and lactation exerts a protection on maternal skeleton during pregnancy and lactation in the rats and could be considered as a plausible nutritional option for protecting maternal bone mass during these periods.

Keywords : Gestation; Lactation; Prebiotic; Calcium; Bone density.

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